Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK4 | Q13043 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 2/20 | 0.35 |
| ▸ | BCR | P11274 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | PRKDC | P78527 | 3/20 | 0.34 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.30 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.30 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3542184 | 0.84 | SMN1; SMN2 (0.40) | STK4SMN1; SMN2ABL1BCRCYP11B1 | |
| SCHEMBL25462583 | 0.83 | STK4 (0.51) | STK4ALDH1A1TSHRPRKDCRPS6KA3 | |
| SCHEMBL2874984 | 0.82 | RPS6KA3 (0.36) | STK4SMN1; SMN2ABL1BCRPRKDC | |
| SCHEMBL2875624 | 0.81 | PRKDC (0.47) | STK4SMN1; SMN2PRKDCPIK3CDPIK3CA | |
| SCHEMBL13814859 | 0.81 | SMN1; SMN2 (0.39) | STK4SMN1; SMN2ABL1BCRMAPT | |
| SCHEMBL25463701 | 0.81 | STK4 (0.52) | STK4ALDH1A1TSHRPRKDCRPS6KA3 | |
| SCHEMBL6844375 | 0.79 | PRKDC (0.45) | STK4SMN1; SMN2ABL1BCRPRKDC | |
| SCHEMBL6840359 | 0.79 | PRKDC (0.45) | PRKDCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL11916076 | 0.78 | STK4 (0.47) | STK4ALDH1A1TSHRPRKDCRPS6KA3 | |
| SCHEMBL7747078 | 0.78 | RPS6KA3 (0.36) | STK4SMN1; SMN2ALDH1A1RPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11572364-B2 | Pteridinone compounds and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2023-02-07 | — | — | US | disclosed |
| WO-2011079118-A1 | PTERIDINONES AS INHIBITORS OF POLO-LIKE KINASE | ELAN PHARMACEUTICALS, INC (US) | 2011-06-30 | — | — | WO | disclosed |
| US-7759347-B2 | 2-benzylaminodihydropteridinones, process for their manufacture and use thereof as medicaments | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-07-20 | — | — | US | disclosed |
| US-7759347-B2 | 2-benzylaminodihydropteridinones, process for their manufacture and use thereof as medicaments | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-07-20 | — | — | US | disclosed |
| US-20090124628-A1 | 2-benzylaminodihydropteridinones, process for their manufacture and use thereof as medicaments | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-05-14 | — | — | US | disclosed |
| US-20090124628-A1 | 2-benzylaminodihydropteridinones, process for their manufacture and use thereof as medicaments | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11572364-B2 | Pteridinone compounds and uses thereof | DPYD, PKD1, TYMP | STK4 1716/4885SMN1; SMN2 1711/4885ABL1 1694/4885 |
| US-20090124628-A1 | 2-benzylaminodihydropteridinones, process for their manufacture and use thereof as medicaments | QDPR, DHPS, CYP51A1 | STK4 2738/4885SMN1; SMN2 4805/4885ABL1 2520/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.