Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.50 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.50 |
| ▸ | PPARA | Q07869 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.46 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.46 |
| ▸ | SCN4A | P35499 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6844672 | 1.00 | LMNA (0.52) | LMNAMTNR1AMTNR1BPPARGPPARA | |
| SCHEMBL10829632 | 0.83 | PPARG (0.58) | PPARGPPARASCN4ARAB9ACYP1A2 | |
| SCHEMBL5512521 | 0.81 | LMNA (0.57) | LMNAMTNR1AMTNR1BPPARGPPARA | |
| SCHEMBL7122514 | 0.81 | PPARG (0.53) | MTNR1AMTNR1BPPARGPPARAALOX15 | |
| SCHEMBL4093444 | 0.79 | LMNA (0.54) | LMNAMTNR1AMTNR1BPPARGPPARA | |
| SCHEMBL8468149 | 0.78 | LMNA (0.59) | LMNAMTNR1AMTNR1BPPARGPPARA | |
| SCHEMBL2731803 | 0.78 | LMNA (0.59) | LMNAMTNR1AMTNR1BPPARGPPARA | |
| SCHEMBL5421055 | 0.78 | LMNA (0.59) | LMNAMTNR1AMTNR1BPPARGPPARA | |
| SCHEMBL9283760 | 0.78 | LMNA (0.59) | LMNAMTNR1AMTNR1BPPARGPPARA | |
| SCHEMBL17386434 | 0.77 | LMNA (0.63) | LMNAMTNR1AMTNR1BCYP2D6ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6770775-B2 | REACTING ACID HALIDES WITH A CINCHONA ALKALOID CATALYST AND A BASE TO FORM INTERMEDIATE KETENES, WHICH ARE THEN REACTED WITH ELECTROPHILIC HALOGENATING REAGENTS TO PRODUCE ALPHA-HALO-ESTERS WITH HIGH ENANTIOMERIC EXCESS | WACK HARALD (DE) | 2004-08-03 | — | — | US | claimed |
| US-6770775-B2 | REACTING ACID HALIDES WITH A CINCHONA ALKALOID CATALYST AND A BASE TO FORM INTERMEDIATE KETENES, WHICH ARE THEN REACTED WITH ELECTROPHILIC HALOGENATING REAGENTS TO PRODUCE ALPHA-HALO-ESTERS WITH HIGH ENANTIOMERIC EXCESS | WACK HARALD (DE) | 2004-08-03 | — | — | US | disclosed |
| US-20030050501-A1 | Method of synthesizing optically enriched alpha-halo-esters, and product and composition therefrom | WACK HARALD (DE) | 2003-03-13 | — | — | US | disclosed |