Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | GLA | P06280 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | WDR5 | P61964 | 1/20 | 0.46 |
| ▸ | METAP2 | P50579 | 1/20 | 0.45 |
| ▸ | METAP1 | P53582 | 1/20 | 0.45 |
| ▸ | LDHA | P00338 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | CDC25B | P30305 | 1/20 | 0.43 |
| ▸ | ME2 | P23368 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9618295 | 0.87 | PTPN1 (0.44) | KDM4EALDH1A1GLAHPGDHSD17B10 | |
| SCHEMBL29913819 | 0.85 | KDM4E (0.57) | KDM4EALDH1A1GLAHPGDHSD17B10 | |
| SCHEMBL897607 | 0.84 | KDM4E (0.55) | KDM4EALDH1A1GLAHPGDHSD17B10 | |
| SCHEMBL8574060 | 0.82 | KDM4E (0.53) | KDM4EALDH1A1GLAHPGDHSD17B10 | |
| SCHEMBL2507677 | 0.82 | KDM4E (0.53) | KDM4EALDH1A1GLAHPGDHSD17B10 | |
| Ammonia Solution, Strong SCHEMBL7720474 | 0.82 | KDM4E (0.53) | KDM4EALDH1A1GLAHPGDHSD17B10 | |
| Ammonia Solution, Strong SCHEMBL7720478 | 0.82 | KDM4E (0.53) | KDM4EALDH1A1GLAHPGDHSD17B10 | |
| SCHEMBL10948548 | 0.82 | KDM4E (0.53) | KDM4EALDH1A1GLAHPGDHSD17B10 | |
| SCHEMBL3048092 | 0.81 | KDM4E (0.52) | KDM4EALDH1A1GLAHPGDHSD17B10 | |
| SCHEMBL9250273 | 0.81 | MEN1 (0.61) | KDM4EALDH1A1GLAHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011044506-A2 | SULPHONE COMPOUNDS AND METHODS OF MAKING AND USING SAME | ZAFGEN CORPORATION (US) | 2011-04-14 | — | — | WO | disclosed |
| EP-0666849-A4 | ARYL AND HETEROARYLMETHOXYPHENYL INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS. | ABBOTT LAB (US) | 1995-12-13 | — | — | EP | disclosed |
| EP-0666849-A1 | ARYL AND HETEROARYLMETHOXYPHENYL INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | ABBOTT LABORATORIES (US) | 1995-08-16 | — | — | EP | disclosed |
| WO-1994010148-A1 | ARYL AND HETEROARYLMETHOXYPHENYL INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | ABBOTT LABORATORIES (US) | 1994-05-11 | — | — | WO | disclosed |