Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLCG1 | P19174 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | METAP2 | P50579 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | PTAFR | P25105 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 2/20 | 0.34 |
| ▸ | MMP8 | P22894 | 2/20 | 0.34 |
| ▸ | MMP12 | P39900 | 2/20 | 0.34 |
| ▸ | MMP13 | P45452 | 2/20 | 0.34 |
| ▸ | MMP14 | P50281 | 2/20 | 0.34 |
| ▸ | MMP16 | P51512 | 2/20 | 0.34 |
| ▸ | MMP1 | P03956 | 1/20 | 0.34 |
| ▸ | MMP3 | P08254 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1648256 | 0.89 | PLCG1 (0.41) | PLCG1POLBALDH1A1KDM4EMEN1 | |
| SCHEMBL1648084 | 0.87 | ALDH1A1 (0.43) | ALDH1A1KMT2ASMN1; SMN2TSHRMETAP2 | |
| SCHEMBL1648544 | 0.84 | METAP2 (0.35) | POLBSMN1; SMN2TSHRMETAP2MMP13 | |
| SCHEMBL6844885 | 0.84 | METAP2 (0.33) | ALDH1A1MEN1KMT2ASMN1; SMN2TSHR | |
| SCHEMBL14717327 | 0.84 | METAP2 (0.35) | POLBSMN1; SMN2TSHRMETAP2MMP13 | |
| SCHEMBL14725639 | 0.82 | PLCG1 (0.46) | PLCG1POLBALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL1648329 | 0.80 | CA1 (0.40) | POLBALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL1649073 | 0.80 | TP53 (0.41) | ALDH1A1MEN1KMT2ASMN1; SMN2TSHR | |
| SCHEMBL28104295 | 0.79 | POLB (0.43) | POLBALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL6844882 | 0.79 | LMNA (0.37) | ALDH1A1MEN1KMT2ASMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011044506-A2 | SULPHONE COMPOUNDS AND METHODS OF MAKING AND USING SAME | ZAFGEN CORPORATION (US) | 2011-04-14 | — | — | WO | disclosed |