SCHEMBL684524

SCHEMBL684524

Cc1ccccc1C(=O)N/N=C/c1cc(Cl)cc(Br)c1O

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 9/20 0.60
MEN1 O00255 7/20 0.60
HTT P42858 6/20 0.60
MAPT P10636 6/20 0.60
KDM4E B2RXH2 6/20 0.60
MAPK1 P28482 2/20 0.55
ALDH1A1 P00352 1/20 0.55
SAE1 Q9UBE0 1/20 0.55
UBA2 Q9UBT2 1/20 0.55
PIK3CG P48736 3/20 0.55
SMN1; SMN2 Q16637 5/20 0.54
RAB9A P51151 3/20 0.54
NPC1 O15118 2/20 0.54
SIRT1 Q96EB6 5/20 0.53
FTO Q9C0B1 1/20 0.53
LMNA P02545 4/20 0.51
ALOX12 P18054 1/20 0.51
POLB P06746 2/20 0.50
CYP1A2 P05177 1/20 0.50
CYP3A4 P08684 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL685198 0.92 KMT2A (0.56) KMT2AMEN1HTTMAPTKDM4E
SCHEMBL684550 0.89 KMT2A (0.74) KMT2AMEN1HTTMAPTKDM4E
SCHEMBL684773 0.88 PIK3CG (0.69) KMT2AMEN1HTTMAPTKDM4E
SCHEMBL26974435 0.88 PIK3CG (0.69) KMT2AMEN1HTTMAPTKDM4E
SCHEMBL1638610 0.88 KMT2A (0.65) KMT2AMEN1HTTMAPTKDM4E
SCHEMBL1638608 0.88 KMT2A (0.65) KMT2AMEN1HTTMAPTKDM4E
SCHEMBL684620 0.88 KMT2A (0.65) KMT2AMEN1HTTMAPTKDM4E
SCHEMBL26974365 0.88 PIK3CG (0.60) KMT2AMEN1HTTMAPTKDM4E
SCHEMBL684554 0.88 KMT2A (0.65) KMT2AMEN1HTTMAPTKDM4E
SCHEMBL684826 0.86 KMT2A (0.60) KMT2AMEN1HTTMAPTKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8906829-B2 Synergistic algicidal compositions including hydrazone derivatives and copper DOW AGROSCIENCES LLC (US) 2014-12-09 US disclosed
US-8906829-B2 Synergistic algicidal compositions including hydrazone derivatives and copper DOW AGROSCIENCES LLC (US) 2014-12-09 US disclosed
US-20120046170-A1 SYNERGISTIC ALGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-02-23 US disclosed
US-20120046170-A1 SYNERGISTIC ALGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-02-23 US disclosed
WO-2012024494-A1 SYNERGISTIC ALGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-02-23 WO disclosed
US-20120010075-A1 SYNERGISTIC FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-01-12 US disclosed
US-20120010075-A1 SYNERGISTIC FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-01-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120010075-A1 SYNERGISTIC FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER SOD1, CYP51A1, SOD3 KMT2A 1362/4885MEN1 536/4885HTT 386/4885
US-20120046170-A1 SYNERGISTIC ALGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER ALG1, SOD1, DHPS KMT2A 2866/4885MEN1 3435/4885HTT 700/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.