Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAOA | P21397 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 7/20 | 0.38 |
| ▸ | RAB9A | P51151 | 5/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | TTR | P02766 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15889096 | 0.87 | NPC1 (0.40) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL653724 | 0.82 | RAB9A (0.62) | KDM4EALDH1A1MEN1KMT2AMAOA | |
| SCHEMBL570295 | 0.82 | KMT2A (0.47) | KDM4EALDH1A1MEN1KMT2AMAOA | |
| SCHEMBL30641650 | 0.80 | KDM4E (0.64) | KDM4EALDH1A1MEN1KMT2AMAOA | |
| SCHEMBL30593474 | 0.80 | KDM4E (0.64) | KDM4EALDH1A1MEN1KMT2AMAOA | |
| SCHEMBL654368 | 0.80 | KDM4E (0.64) | KDM4EALDH1A1MEN1KMT2AMAOA | |
| SCHEMBL14076685 | 0.78 | CA12 (0.41) | KDM4EALDH1A1MEN1KMT2AMAOA | |
| SCHEMBL2763220 | 0.78 | PON1 (0.44) | KDM4EALDH1A1MEN1KMT2AMAOA | |
| SCHEMBL652026 | 0.77 | MAPT (0.51) | KDM4EALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL14684135 | 0.77 | MAOA (0.67) | KDM4EALDH1A1MEN1KMT2AMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011115938-A1 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETA - SECRETASE MODULATORS | AMGEN INC. (US) | 2011-09-22 | — | — | WO | disclosed |
| WO-2010030954-A1 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETASECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2010-03-18 | — | — | WO | disclosed |