SCHEMBL6845346

SCHEMBL6845346

Cc1c(N)c2ccc(-c3ccccc3)cc2oc1=O

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ERAP1 Q9NZ08 1/20 0.49
HSD11B1 P28845 1/20 0.46
HSD17B3 P37058 1/20 0.44
MAOB P27338 4/20 0.44
ACHE P22303 2/20 0.44
CYP1A1 P04798 1/20 0.44
CYP1A2 P05177 1/20 0.44
CYP1B1 Q16678 1/20 0.44
ALDH1A1 P00352 2/20 0.44
GAA P10253 2/20 0.44
KDM4E B2RXH2 1/20 0.44
CYP3A4 P08684 1/20 0.43
CYP2C9 P11712 1/20 0.43
TSHR P16473 1/20 0.43
CYP2C19 P33261 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
MGAM O43451 1/20 0.42
SI P14410 1/20 0.42
MGAM2 Q2M2H8 1/20 0.42
PRKDC P78527 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL94134 0.79 GAA (0.69) ALDH1A1GAAKDM4EMGAMSI
Acetic Acid SCHEMBL472754 0.75 POLB (0.60) ALDH1A1GAAKDM4EMGAMSI
SCHEMBL23106356 0.74 ALDH2 (0.46) ERAP1HSD11B1CYP1A2ALDH1A1GAA
SCHEMBL15842699 0.73 ALDH1A1 (0.61) HSD17B3MAOBCYP1A2ALDH1A1GAA
SCHEMBL13699672 0.73 KDM4E (0.50) HSD11B1ALDH1A1KDM4ETDP1
SCHEMBL10688472 0.72 ERAP1 (0.52) ERAP1HSD11B1HSD17B3MAOBCYP1A2
SCHEMBL10110901 0.72 PRKDC (0.47) HSD11B1HSD17B3MAOBCYP1A2CYP1B1
Dimethylamine SCHEMBL961005 0.72 MAP2K1 (0.59) ERAP1HSD17B3ACHEALDH1A1GAA
SCHEMBL9917216 0.72 HPGD (0.48) MAOBALDH1A1GAAKDM4ECYP3A4
SCHEMBL17523443 0.72 HPGD (0.48) MAOBALDH1A1GAAKDM4ECYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6770385-B2 GOOD LUMINESCENCE AND EXCELLENT THERMAL STABILITY CANON INC. (JP) 2004-08-03 US claimed
US-20030164499-A1 Fluorescent bis-coumarins for organic light-emitting devices CANON KABUSHIKI KAISHA (JP) 2003-09-04 US claimed
US-6770385-B2 GOOD LUMINESCENCE AND EXCELLENT THERMAL STABILITY CANON INC. (JP) 2004-08-03 US disclosed
US-20030164499-A1 Fluorescent bis-coumarins for organic light-emitting devices CANON KABUSHIKI KAISHA (JP) 2003-09-04 US disclosed