Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
| ▸ | ASPH | Q12797 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | DAO | P14920 | 1/20 | 0.35 |
| ▸ | GABRP | O00591 | 2/20 | 0.35 |
| ▸ | GABRD | O14764 | 2/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14549152 | 0.82 | SMN1; SMN2 (0.36) | SMN1; SMN2LMNAKDM4EALDH1A1TSHR | |
| SCHEMBL29378297 | 0.79 | SMN1; SMN2 (0.48) | SMN1; SMN2LMNAKEAP1NFE2L2ASPH | |
| SCHEMBL915781 | 0.79 | SMN1; SMN2 (0.48) | SMN1; SMN2LMNAKEAP1NFE2L2ASPH | |
| SCHEMBL8272694 | 0.78 | TSHR (0.41) | SMN1; SMN2LMNAKDM4EALDH1A1TSHR | |
| SCHEMBL353523 | 0.78 | KDM4E (0.44) | SMN1; SMN2LMNAASPHKDM4EKDM8 | |
| Hydrochloric Acid SCHEMBL6988496 | 0.78 | SMN1; SMN2 (0.47) | SMN1; SMN2LMNAKEAP1NFE2L2ASPH | |
| SCHEMBL3517645 | 0.78 | HCAR2 (0.48) | SMN1; SMN2LMNAKEAP1NFE2L2KDM4E | |
| SCHEMBL4719997 | 0.78 | SMN1; SMN2 (0.47) | SMN1; SMN2LMNAKEAP1NFE2L2ASPH | |
| SCHEMBL290570 | 0.76 | KEAP1 (0.53) | SMN1; SMN2LMNAKEAP1NFE2L2ASPH | |
| SCHEMBL12183992 | 0.76 | NAPRT (0.46) | SMN1; SMN2LMNAASPHKDM4EKDM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011115938-A1 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETA - SECRETASE MODULATORS | AMGEN INC. (US) | 2011-09-22 | — | — | WO | disclosed |
| EP-1899334-B1 | NAPHTHYRIDINE COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2008-09-24 | — | — | EP | disclosed |
| EP-1798230-A1 | Substituted alkylamine derivatives and methods of use | Amgen Inc. (US) | 2007-06-20 | — | — | EP | disclosed |