Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1SLC9A3
The experimentally established mechanism targets of L-Lactic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| L-Lactic Acid SCHEMBL4836154 | 0.95 | LMNA (0.47) | LMNAALDH1A1SLC22A16TDP1TP53 | |
| Glycerin SCHEMBL10693196 | 0.83 | LMNA (0.53) | LMNAALDH1A1SLC22A16TDP1CA4 | |
| Glycerin SCHEMBL10693194 | 0.83 | LMNA (0.53) | LMNAALDH1A1SLC22A16TDP1CA4 | |
| Glycerin SCHEMBL5030995 | 0.83 | LMNA (0.60) | LMNAALDH1A1SLC22A16TDP1TP53 | |
| L-Lactic Acid SCHEMBL992199 | 0.83 | — | — | |
| L-Lactic Acid SCHEMBL29351424 | 0.83 | TP53 (0.50) | LMNAALDH1A1TP53CA4CA2 | |
| L-Lactic Acid SCHEMBL4319 | 0.83 | TP53 (0.50) | LMNAALDH1A1TP53CA4CA2 | |
| L-Lactic Acid SCHEMBL29683322 | 0.83 | TP53 (0.50) | LMNAALDH1A1TP53CA4CA2 | |
| L-Lactic Acid SCHEMBL4648043 | 0.83 | TP53 (0.50) | LMNAALDH1A1TP53CA4CA2 | |
| L-Lactic Acid SCHEMBL2419423 | 0.83 | TP53 (0.50) | LMNAALDH1A1TP53CA4CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0472260-B2 | Braided suture of improved characteristics | UNITED STATES SURGICAL CORP (US) | 2004-04-28 | — | — | EP | disclosed |
| US-6260699-B1 | Packaged synthetic absorbable surgical elements | UNITED STATES SURGICAL CORPORATION | 2001-07-17 | — | — | US | disclosed |
| EP-0625356-B1 | Braided suture | UNITED STATES SURGICAL CORP (US) | 2000-02-02 | — | — | EP | disclosed |
| EP-0472260-B1 | Braided suture of improved characteristics | UNITED STATES SURGICAL CORP (US) | 2000-02-02 | — | — | EP | disclosed |
| US-5569302-A | CYANOACRYLATE RESIN | UNITED STATES SURGICAL CORPORATION (US) | 1996-10-29 | — | — | US | disclosed |
| EP-0499048-B1 | Method and apparatus for calendering and coating/filling sutures | UNITED STATES SURGICAL CORP (US) | 1996-10-09 | — | — | EP | disclosed |
| US-5540773-A | ROTATING CYLINDERS ON FRAMES AND APPLYING FLUIDS | UNITED STATES SURGICAL CORPORATION (US) | 1996-07-30 | — | — | US | disclosed |
| EP-0490143-B1 | Method and apparatus for tipping sutures | UNITED STATES SURGICAL CORP (US) | 1996-01-31 | — | — | EP | disclosed |
| US-5468252-A | Filled suture | UNITED STATES SURGICAL CORPORATION (US) | 1995-11-21 | — | — | US | disclosed |
| US-5462162-A | Packaged synthetic absorbable surgical elements | UNITED STATES SURGICAL CORPORATION (US) | 1995-10-31 | — | — | US | disclosed |
| US-5181923-A | Braid with coating to reduce drag on tissues | UNITED STATES SURGICAL CORPORATION (US) | 1993-01-26 | — | — | US | disclosed |
| EP-0499048-A1 | Method and apparatus for calendering and coating/filling sutures | United States Surgical Corporation (US) | 1992-08-19 | — | — | EP | disclosed |
| EP-0497026-A1 | Method for improving the storage stability of a polymeric article susceptible to hydrolytic degradation and resulting article | United States Surgical Corporation (US) | 1992-08-05 | — | — | EP | disclosed |
| US-5133738-A | COMBINED SURGICAL NEEDLE-SPIROID BRAIDED SUTURE DEVICE | UNITED STATES SURGICAL CORPORATION (US) | 1992-07-28 | — | — | US | disclosed |
| EP-0490143-A2 | Method and apparatus for tipping sutures | United States Surgical Corporation (US) | 1992-06-17 | — | — | EP | disclosed |
| EP-0472260-A1 | Braided suture of improved characteristics | United States Surgical Corporation (US) | 1992-02-26 | — | — | EP | disclosed |
| EP-0471441-A1 | Packaged synthetic absorbable surgical elements | United States Surgical Corporation (US) | 1992-02-19 | — | — | EP | disclosed |
| US-5081150-A | Drugs, cosmetics, foods | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-01-14 | — | — | US | disclosed |
| EP-0449431-A2 | Braided suture | United States Surgical Corporation (US) | 1991-10-02 | — | — | EP | disclosed |
| US-5051272-A | Sutures from polymers which are stable for storage | UNITED STATES SURGICAL CORPORATION (US) | 1991-09-24 | — | — | US | disclosed |