Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1SLC9A3
The experimentally established mechanism targets of L-Lactic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| L-Lactic Acid SCHEMBL6846060 | 0.95 | LMNA (0.47) | LMNAALDH1A1CA2SLC22A16CA4 | |
| Glycerin SCHEMBL15453340 | 0.83 | LMNA (0.53) | LMNAALDH1A1CA2SLC22A16CA4 | |
| L-Lactic Acid SCHEMBL28212831 | 0.83 | CYP3A4 (0.46) | LMNACA2CA4CA1CYP3A4 | |
| Glycerin SCHEMBL9509912 | 0.83 | LMNA (0.60) | LMNAALDH1A1CA2SLC22A16CA4 | |
| Glycerin SCHEMBL27520568 | 0.83 | LMNA (0.60) | LMNAALDH1A1CA2SLC22A16CA4 | |
| L-Lactic Acid SCHEMBL1333089 | 0.83 | — | — | |
| L-Lactic Acid SCHEMBL7999572 | 0.83 | TP53 (0.50) | CA2CA4CA1CYP3A4TSHR | |
| L-Lactic Acid SCHEMBL186171 | 0.83 | — | — | |
| L-Lactic Acid SCHEMBL1332699 | 0.83 | — | — | |
| L-Lactic Acid SCHEMBL4360 | 0.83 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7427397-B2 | Probiotic propionibacterium | UNIVERSITY OF NEWCASTLE RESEARCH ASSOCIATES (TUNRA) LTD. (AU) | 2008-09-23 | — | — | US | disclosed |
| EP-1527159-A4 | PROBIOTIC PROPIONIBACTERIUM JENSENII 702 | UNIV NEWCASTLE RES ASS (AU) | 2006-10-04 | — | — | EP | disclosed |
| US-20050180963-A1 | Probiotic propionibacterium | UNIVERSITY OF NEWCASTLE RESEARCH ASSOCIATES (TUNRA) LTD. | 2005-08-18 | — | — | US | disclosed |
| EP-1527159-A1 | PROBIOTIC PROPIONIBACTERIUM JENSENII 702 | THE UNIVERSITY OF NEWCASTLE RESEARCH ASSOCIATES LIMITED (AU) | 2005-05-04 | — | — | EP | disclosed |
| WO-2004001022-A1 | PROBIOTIC PROPIONIBACTERIUM JENSENII 702 | THE UNIVERSITY OF NEWCASTLE RESEARCH ASSOCIATES (TUNRA) LTD (AU) | 2003-12-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050180963-A1 | Probiotic propionibacterium | FOLH1, FBP1, GUSB | LMNA 1583/4885ALDH1A1 871/4885CA2 1909/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.