Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 8/20 | 0.54 |
| ▸ | CYP11B2 | P19099 | 8/20 | 0.54 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.45 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.45 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.45 |
| ▸ | FNTA | P49354 | 1/20 | 0.44 |
| ▸ | FNTB | P49356 | 1/20 | 0.44 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7259729 | 0.82 | CYP11B1 (0.61) | CYP11B1CYP11B2FNTAFNTBPGGT1B | |
| SCHEMBL13687204 | 0.76 | CHRNB2 (0.61) | CHRNB2CHRNB4CHRNA3CHRNA4NPC1 | |
| SCHEMBL16892166 | 0.75 | CYP11B1 (0.60) | CYP11B1CYP11B2FNTAFNTBPGGT1B | |
| SCHEMBL6776094 | 0.73 | CYP11B1 (0.62) | CYP11B1CYP11B2FNTAFNTBPGGT1B | |
| SCHEMBL2789150 | 0.72 | CYP11B1 (0.61) | CYP11B1CYP11B2FNTAFNTBPGGT1B | |
| SCHEMBL14476557 | 0.72 | CYP11B1 (0.57) | CYP11B1CYP11B2FNTAFNTBPGGT1B | |
| SCHEMBL2789863 | 0.72 | CYP11B1 (0.76) | CYP11B1CYP11B2FNTAFNTBPGGT1B | |
| SCHEMBL698418 | 0.72 | CHRNB2 (0.60) | CHRNB2CHRNB4CHRNA3CHRNA4NPC1 | |
| SCHEMBL20683501 | 0.71 | CHRNB2 (0.53) | CHRNB2CHRNB4CHRNA3CHRNA4NPC1 | |
| SCHEMBL16886091 | 0.71 | CYP11B1 (0.54) | CYP11B1CYP11B2FNTAFNTBPGGT1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6699898-B2 | METHOD OF TREATING CORONARY ARTERY DISEASE OR OTHER CETP-MEDIATED DISORDERS IN A SUBJECT BY ADMINISTERING A THERAPEUTICALLY EFFECTIVE AMOUNT OF A COMPOUND OF ONE OF CLAIMS | PHARMACIA CORPORATION GLOBAL PATENT DEPARTMENT | 2004-03-02 | — | — | US | disclosed |