Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.41 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.41 |
| ▸ | LONP1 | P36776 | 4/20 | 0.41 |
| ▸ | PSMB11 | A5LHX3 | 3/20 | 0.41 |
| ▸ | PSMA7 | O14818 | 3/20 | 0.41 |
| ▸ | PSMB1 | P20618 | 3/20 | 0.41 |
| ▸ | PSMA1 | P25786 | 3/20 | 0.41 |
| ▸ | PSMA2 | P25787 | 3/20 | 0.41 |
| ▸ | PSMA3 | P25788 | 3/20 | 0.41 |
| ▸ | PSMA4 | P25789 | 3/20 | 0.41 |
| ▸ | PSMB8 | P28062 | 3/20 | 0.41 |
| ▸ | PSMB9 | P28065 | 3/20 | 0.41 |
| ▸ | PSMA5 | P28066 | 3/20 | 0.41 |
| ▸ | PSMB4 | P28070 | 3/20 | 0.41 |
| ▸ | PSMB6 | P28072 | 3/20 | 0.41 |
| ▸ | PSMB5 | P28074 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6847570 | 0.80 | KDM4E (0.50) | SMN1; SMN2KDM4ENAPRTHCAR2NPC1 | |
| SCHEMBL13517651 | 0.80 | CTNNB1 (0.50) | SMN1; SMN2KDM4EALDH1A1HTTMEN1 | |
| SCHEMBL6847640 | 0.77 | KDM4E (0.47) | SMN1; SMN2KDM4ENAPRTHCAR2TSHR | |
| SCHEMBL13518195 | 0.75 | LONP1 (0.40) | SMN1; SMN2KDM4EALDH1A1MAPK1NAPRT | |
| SCHEMBL9946197 | 0.73 | KDM4E (0.53) | SMN1; SMN2KDM4EALDH1A1NAPRTHCAR2 | |
| SCHEMBL8509785 | 0.73 | KDM4E (0.53) | SMN1; SMN2KDM4EALDH1A1MAPK1NAPRT | |
| SCHEMBL13517810 | 0.72 | KMT2A (0.56) | SMN1; SMN2KDM4EALDH1A1NAPRTHCAR2 | |
| SCHEMBL13518593 | 0.71 | LMNA (0.51) | SMN1; SMN2KDM4EALDH1A1POLBLMNA | |
| SCHEMBL13517842 | 0.70 | KDM4E (0.39) | SMN1; SMN2KDM4ENAPRTHCAR2NPC1 | |
| SCHEMBL6603504 | 0.70 | KDM4E (0.53) | SMN1; SMN2KDM4EALDH1A1NAPRTHCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8937091-B2 | Inhibitor of protein crosslinking and use of the same | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2015-01-20 | — | — | US | disclosed |
| US-8937091-B2 | Inhibitor of protein crosslinking and use of the same | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2015-01-20 | — | — | US | disclosed |
| US-8937091-B2 | Inhibitor of protein crosslinking and use of the same | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2015-01-20 | — | — | US | disclosed |
| US-20120277423-A1 | PROTEIN CROSSLINKING INHIBITOR AND USE OF THE SAME | JAPAN SCIENCE AND TECHNOLOGY AGENCY | 2012-11-01 | — | — | US | disclosed |
| US-20120277423-A1 | PROTEIN CROSSLINKING INHIBITOR AND USE OF THE SAME | JAPAN SCIENCE AND TECHNOLOGY AGENCY | 2012-11-01 | — | — | US | disclosed |
| US-20120277423-A1 | PROTEIN CROSSLINKING INHIBITOR AND USE OF THE SAME | JAPAN SCIENCE AND TECHNOLOGY AGENCY | 2012-11-01 | — | — | US | disclosed |
| WO-2011055561-A1 | PROTEIN CROSSLINKING INHIBITOR AND USE THEREOF | 独立行政法人科学技術振興機構 (JP) | 2011-05-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120277423-A1 | PROTEIN CROSSLINKING INHIBITOR AND USE OF THE SAME | ARGLU1, F12, CDKL1 | SMN1; SMN2 3521/4885KDM4E 1192/4885ALDH1A1 2990/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.