Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.53 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.52 |
| ▸ | MC4R | P32245 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | MC3R | P41968 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.46 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28801662 | 0.87 | KDM4E (0.59) | KDM4ENAPRTHCAR2TSHRADORA3 | |
| SCHEMBL2632671 | 0.84 | KDM4E (0.58) | KDM4ENAPRTHCAR2TSHRADORA3 | |
| SCHEMBL31703690 | 0.80 | KDM4E (0.48) | KDM4ENAPRTHCAR2TSHRADORA3 | |
| SCHEMBL2917895 | 0.80 | POLB (0.51) | KDM4ENAPRTHCAR2TSHRADORA3 | |
| SCHEMBL17709388 | 0.79 | KDM4E (0.52) | KDM4ENAPRTHCAR2TSHRADORA3 | |
| SCHEMBL8940359 | 0.79 | KDM4E (0.52) | KDM4ENAPRTHCAR2TSHRADORA3 | |
| SCHEMBL26673244 | 0.79 | TSHR (0.60) | KDM4ENAPRTHCAR2TSHRADORA3 | |
| Pyrazinamide SCHEMBL30688461 | 0.78 | ADORA3 (0.68) | KDM4ENAPRTHCAR2TSHRADORA3 | |
| SCHEMBL8509785 | 0.77 | KDM4E (0.53) | KDM4ENAPRTHCAR2TSHRADORA3 | |
| SCHEMBL6603504 | 0.77 | KDM4E (0.53) | KDM4ENAPRTHCAR2TSHRADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4179526-A | 2-((METHYLTHIO)METHYL)-3-PHENYL-2-PROPENAL | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1979-12-18 | — | — | US | claimed |
| US-4156029-A | Alpha-substituted alkylidene methionals and uses thereof in foodstuffs and flavors for foodstuffs | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1979-05-22 | — | — | US | claimed |
| US-4064279-A | Alpha-substituted alkylidene methionals and uses thereof in foodstuffs and flavors for foodstuffs | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1977-12-20 | — | — | US | claimed |
| US-4064280-A | Flavoring with α-oxy(oxo)mercaptans | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1977-12-20 | — | — | US | claimed |
| US-4064278-A | FRUIT AND VEGETABLE FOODSTUFFS | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1977-12-20 | — | — | US | claimed |
| US-4024289-A | Flavoring with α-oxy(oxo)mercaptans | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1977-05-17 | — | — | US | claimed |
| US-20210395302-A1 | PEPTIDES FOR ACTIVATION OF CELL SIGNALING IN OSTEOPROGENITOR CELLS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-12-23 | — | — | US | disclosed |
| US-11124498-B2 | Compositions and methods for modulating protease activity | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-09-21 | — | — | US | disclosed |
| US-20200048227-A1 | COMPOSITIONS AND METHODS FOR MODULATING PROTEASE ACTIVITY | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2020-02-13 | — | — | US | disclosed |
| US-20130149249-A1 | IMAGING TUBERCULOSIS WITH PYRAZINAMIDE CONTRAST AGENTS | GE HEALTHCARE LIMITED (GB) | 2013-06-13 | — | — | US | disclosed |
| US-20120149683-A1 | SUBSTITUTED AMINOPIPERIDINES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OF DIABETES | MERCK SHARP & DOHME LLC | 2012-06-14 | — | — | US | disclosed |
| US-20110177612-A1 | Human G Protein-Coupled Receptors and Modulators Thereof for the Treatment of Metabolic-Related Disorders | ARENA PHARMACEUTICALS, INC. | 2011-07-21 | — | — | US | disclosed |
| US-4859775-A | Process for preparing acylpyrazine ethers | PHILIP MORRIS INCORPORATED (US) | 1989-08-22 | — | — | US | disclosed |
| US-4154766-A | Alpha-substituted alkylidene methionals and uses thereof in foodstuffs and flavors for foodstuffs | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1979-05-15 | — | — | US | disclosed |
| US-4108876-A | ORGANOLEPTIC AGENT FOR FOODS | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1978-08-22 | — | — | US | disclosed |
| US-4081480-A | ORGANOLEPTIC, FLAVORS, ODORS, ENHANCEMENT | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1978-03-28 | — | — | US | disclosed |
| US-4064279-A | Alpha-substituted alkylidene methionals and uses thereof in foodstuffs and flavors for foodstuffs | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1977-12-20 | — | — | US | disclosed |
| US-4064280-A | Flavoring with α-oxy(oxo)mercaptans | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1977-12-20 | — | — | US | disclosed |
| US-4064278-A | FRUIT AND VEGETABLE FOODSTUFFS | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1977-12-20 | — | — | US | disclosed |
| US-4024289-A | Flavoring with α-oxy(oxo)mercaptans | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 1977-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210395302-A1 | PEPTIDES FOR ACTIVATION OF CELL SIGNALING IN OSTEOPROGENITOR CELLS | ITGB4, ITGA4, ITGB1 | KDM4E 2319/4885NAPRT 2247/4885HCAR2 3006/4885 |
| US-20130149249-A1 | IMAGING TUBERCULOSIS WITH PYRAZINAMIDE CONTRAST AGENTS | CTPS1, CTPS2, MPI | KDM4E 3261/4885NAPRT 574/4885HCAR2 2369/4885 |
| US-20120149683-A1 | SUBSTITUTED AMINOPIPERIDINES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OF DIABETES | DPP4, DPP3, DPP7 | KDM4E 525/4885NAPRT 2382/4885HCAR2 1394/4885 |
| US-11124498-B2 | Compositions and methods for modulating protease activity | RNASE1, ADAM8, CTRL | KDM4E 3253/4885NAPRT 3686/4885HCAR2 4328/4885 |
| US-20200048227-A1 | COMPOSITIONS AND METHODS FOR MODULATING PROTEASE ACTIVITY | RNASE1, ADAM8, CTRL | KDM4E 3253/4885NAPRT 3686/4885HCAR2 4328/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.