SCHEMBL684747

SCHEMBL684747

O=C(N/N=C/c1ccc(Cl)c(Cl)c1O)c1cccc([N+](=O)[O-])c1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DUSP3 P51452 2/20 0.67
PTPN5 P54829 2/20 0.67
PTPN11 Q06124 2/20 0.67
MAPT P10636 7/20 0.59
ALDH1A1 P00352 4/20 0.59
GFER P55789 1/20 0.59
NPSR1 Q6W5P4 1/20 0.59
LMNA P02545 6/20 0.58
MEN1 O00255 6/20 0.58
KMT2A Q03164 6/20 0.58
SMN1; SMN2 Q16637 2/20 0.58
L3MBTL1 Q9Y468 2/20 0.58
HTT P42858 4/20 0.57
KDM4E B2RXH2 2/20 0.56
NPC1 O15118 2/20 0.56
OPRK1 P41145 2/20 0.56
POLB P06746 2/20 0.56
AGTR1 P30556 1/20 0.56
GAA P10253 1/20 0.56
TDP1 Q9NUW8 2/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL684798 0.89 DUSP3 (0.73) DUSP3PTPN5PTPN11MAPTALDH1A1
SCHEMBL684641 0.86 MAPT (0.58) MAPTALDH1A1LMNAMEN1KMT2A
SCHEMBL28423202 0.85 DUSP3 (0.75) DUSP3PTPN5PTPN11MAPTALDH1A1
SCHEMBL685237 0.85 DUSP3 (0.67) DUSP3PTPN5PTPN11MAPTALDH1A1
SCHEMBL684756 0.84 DUSP3 (0.64) DUSP3PTPN5PTPN11MAPTALDH1A1
SCHEMBL21145695 0.84 DUSP3 (0.84) DUSP3PTPN5PTPN11MAPTALDH1A1
SCHEMBL21145697 0.84 DUSP3 (0.84) DUSP3PTPN5PTPN11MAPTALDH1A1
SCHEMBL685010 0.84 KDM1A (0.67) MAPTALDH1A1LMNAMEN1KMT2A
SCHEMBL683973 0.83 DUSP3 (0.76) DUSP3PTPN5PTPN11MAPTALDH1A1
SCHEMBL684938 0.83 DUSP3 (0.65) DUSP3PTPN5PTPN11MAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8715745-B2 Fungicidal compositions including hydrazone derivatives and copper DOW AGROSCIENCES, LLC. (US) 2014-05-06 US disclosed
US-8715745-B2 Fungicidal compositions including hydrazone derivatives and copper DOW AGROSCIENCES, LLC. (US) 2014-05-06 US disclosed
US-20120010075-A1 SYNERGISTIC FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-01-12 US disclosed
US-20120010075-A1 SYNERGISTIC FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-01-12 US disclosed
US-20120009274-A1 FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-01-12 US disclosed
US-20120009274-A1 FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-01-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120010075-A1 SYNERGISTIC FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER SOD1, CYP51A1, SOD3 DUSP3 858/4885PTPN5 1027/4885PTPN11 1940/4885
US-20120009274-A1 FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER SOD1, CYP51A1, CYP4Z1 DUSP3 1332/4885PTPN5 1156/4885PTPN11 2177/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.