Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.53 |
| ▸ | DRD3 | P35462 | 6/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.53 |
| ▸ | CHRM4 | P08173 | 5/20 | 0.53 |
| ▸ | CHRM5 | P08912 | 5/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.53 |
| ▸ | CHRM3 | P20309 | 5/20 | 0.53 |
| ▸ | DRD4 | P21917 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.49 |
| ▸ | GSK3A | P49840 | 2/20 | 0.49 |
| ▸ | GSK3B | P49841 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | MGLL | Q99685 | 1/20 | 0.44 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6300376 | 0.92 | CHRM2 (0.52) | DRD2DRD3CHRM2CHRM4CHRM5 | |
| SCHEMBL9835589 | 0.87 | GSK3A (0.59) | ALDH1A1ALDH2PKMALDH3A1GSK3A | |
| SCHEMBL6302300 | 0.82 | POLB (0.65) | DRD2DRD3CHRM2CHRM4CHRM5 | |
| SCHEMBL6302307 | 0.81 | MAPT (0.50) | DRD2DRD3CHRM2CHRM4CHRM5 | |
| SCHEMBL6300286 | 0.77 | ATAD2 (0.43) | DRD2DRD3CHRM2CHRM4CHRM5 | |
| SCHEMBL6300067 | 0.77 | HTR7 (0.40) | DRD2DRD3CHRM2CHRM4CHRM5 | |
| SCHEMBL6768550 | 0.77 | ALDH1A1 (0.54) | DRD3ALDH1A1HTR7HTR1ARAB9A | |
| SCHEMBL6849564 | 0.77 | CHRM2 (0.39) | DRD2DRD3CHRM2CHRM4CHRM5 | |
| SCHEMBL21257673 | 0.76 | HRH1 (0.56) | DRD2DRD3CHRM2CHRM4CHRM5 | |
| SCHEMBL31033176 | 0.75 | ALDH1A1 (0.51) | DRD2DRD3CHRM2CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6774125-B2 | TREATING ALZHEIMER'S DISEASE | ELAN PHARMACEUTICALS, INC. | 2004-08-10 | — | — | US | disclosed |
| US-6509331-B1 | Bicyclic amides such as 5-('-(2S-hydroxy-3-methylbutyrl)-2S-aminopropyl)amino-7-methyl-5,7-dihydro -6H-dibenz(b,d)azepin-6-one | ELAN PHARMACEUTICALS, INC. | 2003-01-21 | — | — | US | disclosed |