Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 11/20 | 0.51 |
| ▸ | CYP19A1 | P11511 | 7/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6847717 | 1.00 | NOTUM (0.51) | NOTUMCYP19A1KEAP1 | |
| SCHEMBL6847719 | 1.00 | NOTUM (0.51) | NOTUMCYP19A1KEAP1 | |
| SCHEMBL6852346 | 0.79 | KDM4E (0.55) | NOTUM | |
| SCHEMBL6852332 | 0.79 | KDM4E (0.55) | NOTUM | |
| SCHEMBL6852339 | 0.79 | KDM4E (0.55) | NOTUM | |
| SCHEMBL6852221 | 0.75 | NOTUM (0.50) | NOTUMCYP19A1KEAP1 | |
| SCHEMBL6852216 | 0.75 | NOTUM (0.50) | NOTUMCYP19A1KEAP1 | |
| SCHEMBL6852443 | 0.74 | QPCT (0.41) | — | |
| SCHEMBL6852438 | 0.74 | QPCT (0.41) | — | |
| SCHEMBL6852433 | 0.74 | QPCT (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6825170-B2 | ERYTHROMYCIN TYPE MACROLIDE WITH A FUSED OXAZOLONE RING | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2004-11-30 | — | — | US | disclosed |
| EP-1453847-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003050132-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2003-06-19 | — | — | WO | disclosed |