Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 1/20 | 0.53 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.53 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.53 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | PREP | P48147 | 3/20 | 0.49 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.49 |
| ▸ | KLK7 | P49862 | 1/20 | 0.47 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.47 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27602555 | 0.92 | SMN1; SMN2 (0.56) | PDK1PDK2PDK3PDK4SMN1; SMN2 | |
| SCHEMBL27677079 | 0.92 | SMN1; SMN2 (0.56) | PDK1PDK2PDK3PDK4SMN1; SMN2 | |
| SCHEMBL19120482 | 0.87 | PDK1 (0.52) | PDK1PDK2PDK3PDK4SMN1; SMN2 | |
| SCHEMBL4676650 | 0.87 | PDK1 (0.54) | PDK1PDK2PDK3PDK4SMN1; SMN2 | |
| SCHEMBL28913512 | 0.86 | PDK1 (0.51) | PDK1PDK2PDK3PDK4SMN1; SMN2 | |
| SCHEMBL2419018 | 0.86 | PDK1 (0.51) | PDK1PDK2PDK3PDK4SMN1; SMN2 | |
| SCHEMBL8487526 | 0.86 | SMN1; SMN2 (0.54) | PDK1PDK2PDK3PDK4SMN1; SMN2 | |
| SCHEMBL781549 | 0.85 | SMN1; SMN2 (0.60) | PDK1PDK2PDK3PDK4SMN1; SMN2 | |
| SCHEMBL7647340 | 0.85 | SMN1; SMN2 (0.60) | PDK1PDK2PDK3PDK4SMN1; SMN2 | |
| SCHEMBL631581 | 0.85 | FKBP1A (0.58) | SMN1; SMN2NPC1RAB9ACYP2C19PREP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874852-B1 | OXAZOLIDINONE ANTIBACTERIAL AGENT WITH TRICYCLIC SUBSTITUENTS | UPJOHN CO (US) | 2004-03-31 | — | — | EP | disclosed |
| EP-0874852-A1 | OXAZOLIDINONE ANTIBACTERIAL AGENT WITH TRICYCLIC SUBSTITUENTS | PHARMACIA & UPJOHN COMPANY (US) | 1998-11-04 | — | — | EP | disclosed |
| WO-1997019089-A1 | OXAZOLIDINONE ANTIBACTERIAL AGENT WITH TRICYCLIC SUBSTITUENTS | PHARMACIA & UPJOHN COMPANY (US) | 1997-05-29 | — | — | WO | disclosed |