Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.33 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.33 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 2/20 | 0.32 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.32 |
| ▸ | RAF1 | P04049 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.30 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6832126 | 0.81 | — | — | |
| Hydrochloric Acid SCHEMBL6835299 | 0.72 | — | — | |
| Hydrochloric Acid SCHEMBL6698527 | 0.70 | KMT2A (0.31) | — | |
| Hydrochloric Acid SCHEMBL6848151 | 0.69 | GRM4 (0.34) | HDAC3HDAC8HDAC6KCNJ6KCNJ5 | |
| Hydrochloric Acid SCHEMBL6858910 | 0.69 | MAPT (0.33) | — | |
| Hydrochloric Acid SCHEMBL6864998 | 0.67 | RAPGEF4 (0.33) | — | |
| Hydrochloric Acid SCHEMBL6848155 | 0.67 | HDAC3 (0.33) | HDAC3HDAC8HDAC6KCNJ6KCNJ5 | |
| SCHEMBL9290330 | 0.63 | HDAC8 (0.47) | HDAC3HDAC8HDAC6KCNJ6KCNJ5 | |
| SCHEMBL21625856 | 0.63 | KIF11 (0.54) | HDAC3HDAC8HDAC6KCNJ6KCNJ5 | |
| SCHEMBL29514710 | 0.63 | KIF11 (0.54) | HDAC3HDAC8HDAC6KCNJ6KCNJ5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004106394-A1 | COPOLYMERS OF ETHYLENE AND/OR α-OLEFINS AND VICINALLY DISUBSTITUTED OLEFINS | EXXONMOBIL CHEMICAL PATENTS INC. (US) | 2004-12-09 | — | — | WO | disclosed |