Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.76 |
| ▸ | RAB9A | P51151 | 6/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.73 |
| ▸ | MAPT | P10636 | 10/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.71 |
| ▸ | HTT | P42858 | 2/20 | 0.71 |
| ▸ | MEN1 | O00255 | 6/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.70 |
| ▸ | LMNA | P02545 | 5/20 | 0.70 |
| ▸ | GAA | P10253 | 4/20 | 0.70 |
| ▸ | POLB | P06746 | 3/20 | 0.70 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.70 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.70 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.70 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.67 |
| ▸ | PKM | P14618 | 1/20 | 0.65 |
| ▸ | BLM | P54132 | 1/20 | 0.65 |
| ▸ | HPGD | P15428 | 3/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28600551 | 0.89 | MAPT (0.80) | NPC1RAB9ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL5445846 | 0.85 | NPC1 (0.71) | NPC1RAB9ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL12495837 | 0.85 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL12316859 | 0.81 | RAB9A (0.78) | NPC1RAB9ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL6849612 | 0.81 | MAPT (0.76) | NPC1RAB9ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL18708218 | 0.80 | NPC1 (0.74) | NPC1RAB9ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL8291149 | 0.80 | NPC1 (0.67) | NPC1RAB9ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL5448299 | 0.79 | NPC1 (0.66) | NPC1RAB9ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL14096529 | 0.79 | ALDH1A1 (0.71) | NPC1RAB9ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL1858799 | 0.78 | RAB9A (0.75) | NPC1RAB9ASMN1; SMN2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011020849-A1 | CYTOHESIN INHIBITORS | RHEINISCHE FRIEDRICH-WILHELMS UNIVERSITÄT (DE) | 2011-02-24 | — | — | WO | disclosed |
| EP-2286808-A1 | Cytohesin inhibitors | Rheinische Friedrich-Wilhelms Universität (DE) | 2011-02-23 | — | — | EP | disclosed |