SCHEMBL684849

SCHEMBL684849

COc1ccc(/C=N/NC(=O)c2ccc(Cl)cc2)c(O)c1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 5/20 0.63
RAB9A P51151 4/20 0.63
MAPT P10636 3/20 0.63
ALDH1A1 P00352 2/20 0.63
BLM P54132 2/20 0.63
SMN1; SMN2 Q16637 2/20 0.63
CTDSP1 Q9GZU7 1/20 0.63
MGAM O43451 2/20 0.61
KMT2A Q03164 7/20 0.61
MEN1 O00255 6/20 0.61
KDM1A O60341 1/20 0.60
POLB P06746 3/20 0.57
NPC1 O15118 2/20 0.57
USP2 O75604 1/20 0.57
LMNA P02545 2/20 0.55
HTT P42858 2/20 0.55
SIRT1 Q96EB6 2/20 0.55
PSMD14 O00487 1/20 0.55
MMP2 P08253 1/20 0.55
MIF P14174 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL685220 0.90 KDM1A (0.67) KDM4ERAB9AMAPTALDH1A1BLM
SCHEMBL12746373 0.89 GUSB (0.65) KDM4ERAB9AMAPTALDH1A1SMN1; SMN2
SCHEMBL13659855 0.88 MGAM (0.61) KDM4ERAB9AMAPTALDH1A1SMN1; SMN2
SCHEMBL7949337 0.88 KMT2A (0.78) KDM4ERAB9AMAPTALDH1A1BLM
SCHEMBL7949340 0.88 KMT2A (0.78) KDM4ERAB9AMAPTALDH1A1BLM
SCHEMBL683790 0.88 MGAM (0.66) KDM4ERAB9AMAPTALDH1A1SMN1; SMN2
SCHEMBL12746249 0.87 KDM1A (0.69) KDM4ERAB9AMAPTALDH1A1BLM
SCHEMBL20750167 0.87 MGAM (0.60) KDM4ERAB9AMAPTALDH1A1BLM
SCHEMBL6751418 0.86 SIRT1 (0.72) KDM4ERAB9ABLMSMN1; SMN2KMT2A
SCHEMBL10049701 0.86 SIRT1 (0.72) KDM4ERAB9ABLMSMN1; SMN2KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3524347-A1 USE OF METAL HYDRAZIDE COMPLEX COMPOUNDS AS OXIDATION CATALYSTS BASF SE (DE) 2019-08-14 EP disclosed
EP-2271426-B1 USE OF HYDRAZIDE COMPOUNDS AS OXIDATION CATALYSTS BASF SE (DE) 2019-02-20 EP disclosed
US-8791298-B2 Use of metal hydrazide complex compounds as oxidation catalysts BASF SE (DE) 2014-07-29 US disclosed
US-8791298-B2 Use of metal hydrazide complex compounds as oxidation catalysts BASF SE (DE) 2014-07-29 US disclosed
US-20130281353-A1 Use of Metal Hydrazide Complex Compounds as Oxidation Catalysts BASF SE (DE) 2013-10-24 US disclosed
US-20130281353-A1 Use of Metal Hydrazide Complex Compounds as Oxidation Catalysts BASF SE (DE) 2013-10-24 US disclosed
US-8492324-B2 Use of metal hydrazide complex compounds as oxidation catalysts BASF SE (DE) 2013-07-23 US disclosed
US-8492324-B2 Use of metal hydrazide complex compounds as oxidation catalysts BASF SE (DE) 2013-07-23 US disclosed
US-20120010075-A1 SYNERGISTIC FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-01-12 US disclosed
US-20120010075-A1 SYNERGISTIC FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER DOW AGROSCIENCES LLC (US) 2012-01-12 US disclosed
US-20110071066-A1 USE OF METAL HYDRAZIDE COMPLEX COMPOUNDS AS OXIDATION CATALYSTS BASF SE (DE) 2011-03-24 US disclosed
US-20110071066-A1 USE OF METAL HYDRAZIDE COMPLEX COMPOUNDS AS OXIDATION CATALYSTS BASF SE (DE) 2011-03-24 US disclosed
WO-2009124855-A1 USE OF METAL HYDRAZIDE COMPLEX COMPOUNDS AS OXIDATION CATALYSTS BASF SE (DE) 2009-10-15 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110071066-A1 USE OF METAL HYDRAZIDE COMPLEX COMPOUNDS AS OXIDATION CATALYSTS SOD1, H1-4, H1-5 KDM4E 348/4885RAB9A 3542/4885MAPT 1770/4885
US-20120010075-A1 SYNERGISTIC FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER SOD1, CYP51A1, SOD3 KDM4E 1473/4885RAB9A 3846/4885MAPT 1491/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.