SCHEMBL6848992

SCHEMBL6848992

CN[C@H](Cc1ccc2ccccc2c1)C(=O)N(C)[C@H](Cc1ccccc1)C(=O)NNC(C)=O

nearest known ligand 0.46

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MMP9 P14780 2/20 0.46
MMP8 P22894 2/20 0.46
FCER2 P06734 3/20 0.46
GHSR Q92847 2/20 0.44
TACR1 P25103 1/20 0.44
CTSL P07711 2/20 0.43
CTSB P07858 2/20 0.43
CTSS P25774 2/20 0.43
MME P08473 4/20 0.43
ACE P12821 3/20 0.43
CPA1 P15085 2/20 0.43
ACE2 Q9BYF1 2/20 0.43
F2 P00734 2/20 0.43
OPRD1 P41143 1/20 0.42
CTSK P43235 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4427112 0.89 FCER2 (0.53) MMP9MMP8FCER2GHSRTACR1
SCHEMBL4426088 0.89 FCER2 (0.53) MMP9MMP8FCER2GHSRTACR1
SCHEMBL6317992 0.89 FCER2 (0.53) MMP9MMP8FCER2GHSRTACR1
SCHEMBL3266812 0.88 MMP9 (0.47) MMP9MMP8FCER2GHSRCTSL
SCHEMBL3266799 0.87 MMP9 (0.45) MMP9MMP8FCER2GHSRTACR1
SCHEMBL8715806 0.87 FCER2 (0.52) MMP9MMP8FCER2GHSRCTSL
SCHEMBL6324655 0.87 MME (0.47) MMP9MMP8FCER2GHSRCTSL
SCHEMBL6320694 0.86 MMP9 (0.56) MMP9MMP8FCER2GHSRCTSL
SCHEMBL3266963 0.86 GHSR (0.47) MMP9MMP8FCER2GHSRTACR1
SCHEMBL8235025 0.85 GHSR (0.49) MMP9MMP8FCER2GHSRCTSL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1047709-B1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES NOVO NORDISK AS (DK) 2004-11-03 EP claimed