Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | GABRA5 | P31644 | 8/20 | 0.49 |
| ▸ | GABRA1 | P14867 | 6/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | PLK1 | P53350 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | PARG | Q86W56 | 2/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6849994 | 0.89 | PLK1 (0.48) | KMT2AMEN1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL6855341 | 0.84 | MAPT (0.51) | PLK1MAPTALDH1A1NPSR1L3MBTL1 | |
| SCHEMBL6855953 | 0.83 | MAPT (0.41) | PLK1MAPTALDH1A1L3MBTL1 | |
| SCHEMBL6850090 | 0.82 | KMT2A (0.36) | PKMKMT2AMEN1CYP1A2CYP3A4 | |
| SCHEMBL6850093 | 0.82 | KMT2A (0.36) | PKMKMT2AMEN1CYP1A2CYP3A4 | |
| SCHEMBL7002215 | 0.81 | PIK3R1 (0.36) | PKMKMT2AMEN1CYP1A2CYP3A4 | |
| SCHEMBL6855211 | 0.81 | PKM (0.49) | PKMKMT2AMEN1CYP1A2CYP3A4 | |
| SCHEMBL6854427 | 0.80 | PIK3R1 (0.48) | PLK1MAPTPARGSRCALDH1A1 | |
| SCHEMBL6850084 | 0.80 | MAPT (0.39) | PLK1MAPTALDH1A1L3MBTL1 | |
| SCHEMBL6849948 | 0.80 | ALDH1A1 (0.41) | PLK1MAPTRXFP1ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6828315-B1 | Anti- inflammatories, anti-allergics, bronchodilatators, anti-asthmatics, or TNF alpha inhibitors | WARNER-LAMBERT LLC | 2004-12-07 | — | — | US | claimed |
| US-6828315-B1 | Anti- inflammatories, anti-allergics, bronchodilatators, anti-asthmatics, or TNF alpha inhibitors | WARNER-LAMBERT LLC | 2004-12-07 | — | — | US | disclosed |
| EP-1177195-B1 | 1-AMINO TRIAZOLO 4,3-a! QUINAZOLINE-5-ONES AND OR -5-THIONES INHIBITING PHOSPHODIESTERASE IV | WARNER LAMBERT CO (US) | 2003-03-19 | — | — | EP | disclosed |
| EP-1177195-A1 | 1-AMINO TRIAZOLO 4,3-a! QUINAZOLINE-5-ONES AND OR -5-THIONES INHIBITING PHOSPHODIESTERASE IV | WARNER-LAMBERT COMPANY (US) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000066584-A1 | 1-AMINO TRIAZOLO¢4,3-a! QUINAZOLINE-5-ONES AND OR -5-THIONES INHIBITING PHOSPHODIESTERASE IV | WARNER-LAMBERT COMPANY (US) | 2000-11-09 | — | — | WO | disclosed |