Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3R1 | P27986 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.34 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | CNR2 | P34972 | 2/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7002218 | 0.84 | GABRA1 (0.33) | PIK3R1PIK3CAMEN1KMT2ACYP1A2 | |
| SCHEMBL6855837 | 0.83 | PIK3R1 (0.44) | PIK3R1PIK3CAMEN1KMT2ACYP1A2 | |
| SCHEMBL6854824 | 0.83 | PIK3R1 (0.44) | PIK3R1PIK3CAMEN1KMT2ACYP1A2 | |
| SCHEMBL6854914 | 0.83 | PKM (0.48) | MEN1KMT2ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6854127 | 0.83 | MAPT (0.43) | MAPTKDM4ECNR2HSD17B10ALDH1A1 | |
| SCHEMBL6854981 | 0.82 | PIK3R1 (0.45) | PIK3R1PIK3CACYP3A4MAPTKDM4E | |
| SCHEMBL6855386 | 0.82 | MAPT (0.44) | MAPTKDM4ECNR2HSD17B10ALDH1A1 | |
| SCHEMBL6855211 | 0.82 | PKM (0.49) | MEN1KMT2ACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6850124 | 0.82 | MAPT (0.46) | PIK3R1PIK3CAMAPTKDM4EHSD17B10 | |
| SCHEMBL7002369 | 0.81 | MAPT (0.39) | KMT2AMAPTKDM4EHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1177195-B1 | 1-AMINO TRIAZOLO 4,3-a! QUINAZOLINE-5-ONES AND OR -5-THIONES INHIBITING PHOSPHODIESTERASE IV | WARNER LAMBERT CO (US) | 2003-03-19 | — | — | EP | claimed |