Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP4 | P49662 | 1/20 | 0.38 |
| ▸ | CASP5 | P51878 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.36 |
| ▸ | PARG | Q86W56 | 1/20 | 0.36 |
| ▸ | PLK1 | P53350 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | GPR183 | P32249 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6854048 | 0.93 | PIK3R1 (0.46) | MAPTTP53PIK3R1PIK3CAHSP90AA1 | |
| SCHEMBL6853783 | 0.89 | ALDH1A1 (0.44) | MAPTTP53HSP90AA1NPSR1LMNA | |
| SCHEMBL6854057 | 0.87 | MAPT (0.42) | MAPTTP53HSP90AA1NPSR1LMNA | |
| SCHEMBL6854129 | 0.86 | MAPT (0.41) | MAPTTP53HSP90AA1NPSR1LMNA | |
| SCHEMBL6855972 | 0.86 | MAPT (0.41) | MAPTTP53HSP90AA1NPSR1LMNA | |
| SCHEMBL6854439 | 0.85 | MAPT (0.51) | MAPTTP53NPSR1LMNATSHR | |
| SCHEMBL6850125 | 0.85 | L3MBTL1 (0.48) | MAPTTP53LMNATSHRPLK1 | |
| SCHEMBL6850007 | 0.84 | L3MBTL1 (0.47) | MAPTTP53CASP1LMNATSHR | |
| SCHEMBL6854145 | 0.84 | L3MBTL1 (0.47) | MAPTTP53CASP1LMNATSHR | |
| SCHEMBL6850222 | 0.84 | MAPT (0.44) | MAPTTP53LMNATSHRPLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6828315-B1 | Anti- inflammatories, anti-allergics, bronchodilatators, anti-asthmatics, or TNF alpha inhibitors | WARNER-LAMBERT LLC | 2004-12-07 | — | — | US | claimed |
| US-6828315-B1 | Anti- inflammatories, anti-allergics, bronchodilatators, anti-asthmatics, or TNF alpha inhibitors | WARNER-LAMBERT LLC | 2004-12-07 | — | — | US | disclosed |
| EP-1177195-B1 | 1-AMINO TRIAZOLO 4,3-a! QUINAZOLINE-5-ONES AND OR -5-THIONES INHIBITING PHOSPHODIESTERASE IV | WARNER LAMBERT CO (US) | 2003-03-19 | — | — | EP | disclosed |