Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 3/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6854057 | 0.91 | MAPT (0.42) | ALDH1A1HPGDHSP90AA1NPSR1LMNA | |
| SCHEMBL6854129 | 0.90 | MAPT (0.41) | ALDH1A1HPGDHSP90AA1NPSR1LMNA | |
| SCHEMBL6855972 | 0.90 | MAPT (0.41) | ALDH1A1HPGDHSP90AA1NPSR1LMNA | |
| SCHEMBL6850259 | 0.89 | MAPT (0.41) | ALDH1A1HPGDHSP90AA1NPSR1LMNA | |
| SCHEMBL6854048 | 0.87 | PIK3R1 (0.46) | ALDH1A1HSP90AA1NPSR1MAPTTP53 | |
| SCHEMBL6854439 | 0.84 | MAPT (0.51) | ALDH1A1HPGDNPSR1LMNATSHR | |
| SCHEMBL6850125 | 0.84 | L3MBTL1 (0.48) | ALDH1A1LMNATSHRMAPTTP53 | |
| SCHEMBL7146999 | 0.84 | PIK3R1 (0.40) | ALDH1A1HPGDLMNATSHRMAPT | |
| SCHEMBL7529993 | 0.84 | PIK3R1 (0.40) | ALDH1A1HPGDLMNATSHRMAPT | |
| SCHEMBL6854145 | 0.83 | L3MBTL1 (0.47) | ALDH1A1HPGDLMNATSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6828315-B1 | Anti- inflammatories, anti-allergics, bronchodilatators, anti-asthmatics, or TNF alpha inhibitors | WARNER-LAMBERT LLC | 2004-12-07 | — | — | US | claimed |
| US-6828315-B1 | Anti- inflammatories, anti-allergics, bronchodilatators, anti-asthmatics, or TNF alpha inhibitors | WARNER-LAMBERT LLC | 2004-12-07 | — | — | US | disclosed |
| EP-1177195-B1 | 1-AMINO TRIAZOLO 4,3-a! QUINAZOLINE-5-ONES AND OR -5-THIONES INHIBITING PHOSPHODIESTERASE IV | WARNER LAMBERT CO (US) | 2003-03-19 | — | — | EP | disclosed |