Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAE1 | Q13564 | 4/20 | 0.74 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.74 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.74 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.74 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.74 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.74 |
| ▸ | PPARG | P37231 | 2/20 | 0.74 |
| ▸ | HTR2B | P41595 | 2/20 | 0.74 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.74 |
| ▸ | MEN1 | O00255 | 1/20 | 0.74 |
| ▸ | MLNR | O43193 | 1/20 | 0.74 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.74 |
| ▸ | USP2 | O75604 | 1/20 | 0.74 |
| ▸ | ESR1 | P03372 | 1/20 | 0.74 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.74 |
| ▸ | TP53 | P04637 | 1/20 | 0.74 |
| ▸ | PGR | P06401 | 1/20 | 0.74 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14522914 | 0.95 | NAE1 (0.75) | NAE1AGTR2CYP3A4ADORA3ADRA2B | |
| SCHEMBL30007325 | 0.95 | NAE1 (0.75) | NAE1AGTR2CYP3A4ADORA3ADRA2B | |
| SCHEMBL6848863 | 0.95 | NAE1 (0.71) | NAE1AGTR2CYP3A4ADORA3ADRA2B | |
| SCHEMBL15478919 | 0.92 | NAE1 (0.74) | NAE1AGTR2CYP3A4ADORA3ADRA2B | |
| SCHEMBL2477228 | 0.90 | AGTR2 (0.71) | NAE1AGTR2CYP3A4ADORA3ADRA2B | |
| SCHEMBL1639019 | 0.89 | NAE1 (0.78) | NAE1AGTR2CYP3A4ADORA3ADRA2B | |
| SCHEMBL5382162 | 0.88 | NAE1 (0.70) | NAE1AGTR2CYP3A4ADORA3ADRA2B | |
| Candesartan Cilexetil SCHEMBL3968703 | 0.86 | NAE1 (0.79) | NAE1AGTR2CYP3A4ADORA3ADRA2B | |
| Candesartan Cilexetil SCHEMBL40831 | 0.86 | NAE1 (0.79) | NAE1AGTR2CYP3A4ADORA3ADRA2B | |
| Candesartan Cilexetil SCHEMBL16949997 | 0.86 | NAE1 (0.79) | NAE1AGTR2CYP3A4ADORA3ADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9527821-B2 | Deprotection method for tetrazole compound | API CORPORATION (JP) | 2016-12-27 | — | — | US | disclosed |
| US-9527821-B2 | Deprotection method for tetrazole compound | API CORPORATION (JP) | 2016-12-27 | — | — | US | disclosed |
| US-20150239854-A1 | DEPROTECTION METHOD FOR TETRAZOLE COMPOUND | API CORPORATION (JP) | 2015-08-27 | — | — | US | disclosed |
| US-20150239854-A1 | DEPROTECTION METHOD FOR TETRAZOLE COMPOUND | API CORPORATION (JP) | 2015-08-27 | — | — | US | disclosed |
| US-8530506-B2 | Process for production of biphenyl derivative | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2013-09-10 | — | — | US | disclosed |
| US-8530506-B2 | Process for production of biphenyl derivative | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2013-09-10 | — | — | US | disclosed |
| US-20120232283-A1 | PROCESS FOR PRODUCTION OF BIPHENYL DERIVATIVE | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2012-09-13 | — | — | US | disclosed |
| US-20120232283-A1 | PROCESS FOR PRODUCTION OF BIPHENYL DERIVATIVE | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2012-09-13 | — | — | US | disclosed |
| WO-2011061996-A1 | PROCESS FOR PRODUCTION OF BIPHENYL DERIVATIVE | 田辺三菱製薬株式会社 (JP) | 2011-05-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150239854-A1 | DEPROTECTION METHOD FOR TETRAZOLE COMPOUND | AGTR2, AGTR1, REN | NAE1 2195/4885AGTR2 1/4885CYP3A4 706/4885 |
| US-20120232283-A1 | PROCESS FOR PRODUCTION OF BIPHENYL DERIVATIVE | AGTR2, AGTR1, ACE | NAE1 854/4885AGTR2 1/4885CYP3A4 22/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.