Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | PRKDC | P78527 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 3/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25536906 | 0.98 | CA2 (0.35) | CA2ALDH1A1HPGDNPSR1PRKDC | |
| SCHEMBL3354467 | 0.75 | POLB (0.41) | ALDH1A1HPGDNPSR1TSHRMAPK1 | |
| SCHEMBL5541190 | 0.74 | ALDH1A1 (0.41) | ALDH1A1HPGDNPSR1TSHRMAPK1 | |
| SCHEMBL5537338 | 0.74 | JAK2 (0.39) | ALDH1A1HPGDNPSR1TSHRMAPK1 | |
| SCHEMBL5543644 | 0.74 | MEN1 (0.38) | ALDH1A1HPGDNPSR1TSHRMAPK1 | |
| SCHEMBL14199897 | 0.71 | TSHR (0.37) | CA2ALDH1A1HPGDNPSR1TSHR | |
| SCHEMBL24656305 | 0.71 | HTR1A (0.38) | CA2ALDH1A1HPGDNPSR1PRKDC | |
| SCHEMBL3552088 | 0.69 | ALDH1A1 (0.38) | ALDH1A1HPGDMAPK1CYP1A2LMNA | |
| SCHEMBL20650931 | 0.66 | CA2 (0.44) | CA2ALDH1A1NPSR1TSHRCYP1A2 | |
| SCHEMBL637681 | 0.66 | PTPN1 (0.41) | ALDH1A1HPGDMAPK1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1394152-A1 | 2-IMINOIMIDAZOLE DERIVATIVES (1) | Eisai Co., Ltd. (JP) | 2004-03-03 | — | — | EP | disclosed |