SCHEMBL6851365

SCHEMBL6851365

COc1cc2cc(-c3ccc(N)cc3[N+](=O)[O-])[nH]c2cc1OC

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EHMT2 Q96KQ7 1/20 0.44
ALDH1A1 P00352 5/20 0.41
CYP3A4 P08684 3/20 0.41
TSHR P16473 2/20 0.41
RECQL P46063 1/20 0.41
TDP1 Q9NUW8 5/20 0.40
ALOX15 P16050 3/20 0.40
HSD17B10 Q99714 2/20 0.38
MAPK1 P28482 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
KDM4E B2RXH2 3/20 0.38
MAPT P10636 3/20 0.38
BLM P54132 1/20 0.38
CYP19A1 P11511 1/20 0.38
HPGD P15428 2/20 0.37
RAB9A P51151 2/20 0.37
SMN1; SMN2 Q16637 2/20 0.37
MEN1 O00255 1/20 0.37
KMT2A Q03164 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6851371 0.76 ALDH1A1 (0.41) ALDH1A1CYP3A4TSHRRECQLTDP1
SCHEMBL225023 0.74 ALDH1A1 (0.47) ALDH1A1TDP1MAPK1KDM4EMAPT
SCHEMBL2211964 0.72 ALDH1A1 (0.59) ALDH1A1CYP3A4TSHRRECQLTDP1
SCHEMBL29453576 0.72 ALDH1A1 (0.59) ALDH1A1CYP3A4TSHRRECQLTDP1
Hydrochloric Acid SCHEMBL15486437 0.71 ALDH1A1 (0.58) ALDH1A1CYP3A4TSHRRECQLTDP1
SCHEMBL2875608 0.70 MAPT (0.55) ALDH1A1MAPK1KDM4EMAPTCYP19A1
SCHEMBL153657 0.70 ALDH1A1 (0.69) ALDH1A1CYP3A4TSHRRECQLTDP1
SCHEMBL358064 0.69 TDP1 (0.58) ALDH1A1CYP3A4TSHRRECQLTDP1
SCHEMBL31648061 0.68 ALDH1A1 (0.50) ALDH1A1CYP3A4TSHRRECQLTDP1
SCHEMBL6923954 0.68 KMT2A (0.53) ALDH1A1TDP1KDM4EMAPTCYP19A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6828443-B1 Dyes and colorants HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) 2004-12-07 US claimed