Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 12/20 | 0.60 |
| ▸ | SLC6A2 | P23975 | 10/20 | 0.60 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.60 |
| ▸ | SLC22A1 | O15245 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.60 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.60 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.60 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.45 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.45 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6851754 | 1.00 | SLC6A4 (0.60) | SLC6A4SLC6A2OPRM1SLC22A1KMT2A | |
| SCHEMBL6851765 | 1.00 | SLC6A4 (0.60) | SLC6A4SLC6A2OPRM1SLC22A1KMT2A | |
| SCHEMBL6851762 | 1.00 | SLC6A4 (0.60) | SLC6A4SLC6A2OPRM1SLC22A1KMT2A | |
| SCHEMBL7079682 | 0.82 | SLC6A4 (0.60) | SLC6A4SLC6A2OPRM1SLC22A1KMT2A | |
| SCHEMBL7066371 | 0.82 | SLC6A4 (0.60) | SLC6A4SLC6A2OPRM1SLC22A1KMT2A | |
| SCHEMBL7079678 | 0.82 | SLC6A4 (0.60) | SLC6A4SLC6A2OPRM1SLC22A1KMT2A | |
| SCHEMBL16115468 | 0.81 | SLC6A4 (0.65) | SLC6A4SLC6A2OPRM1SLC22A1KMT2A | |
| SCHEMBL13941680 | 0.81 | SLC6A4 (0.65) | SLC6A4SLC6A2OPRM1SLC22A1KMT2A | |
| Hydrochloric Acid SCHEMBL8611905 | 0.80 | SLC6A4 (0.64) | SLC6A4SLC6A2OPRM1SLC22A1KMT2A | |
| SCHEMBL14538756 | 0.78 | SLC6A4 (0.76) | SLC6A4SLC6A2OPRM1SLC22A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6780891-B2 | MODULATE OPIATE RECEPTORS; CENTRAL NERVOUS SYSTEM DISORDERS | SEPRACOR INC. | 2004-08-24 | — | — | US | disclosed |
| US-20030171440-A1 | Tramadol analogs and uses thereof | SEPRACOR INC. | 2003-09-11 | — | — | US | disclosed |
| WO-2003048113-A1 | TRAMADOL ANALOGS AND USES THEREOF | SEPRACOR INC. (US) | 2003-06-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030171440-A1 | Tramadol analogs and uses thereof | OPRD1, OPRK1, OPRM1 | SLC6A4 56/4885SLC6A2 81/4885OPRM1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.