Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | RAB9A | P51151 | 3/20 | 0.56 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.50 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.50 |
| ▸ | HPGDS | O60760 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.47 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.47 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2310273 | 0.89 | ALDH1A1 (0.68) | NPC1RAB9AMAPTKMT2APOLB | |
| SCHEMBL7427811 | 0.81 | CTDSP1 (0.60) | NPC1RAB9ACTDSP1MAPTSMN1; SMN2 | |
| Biphenyl SCHEMBL11126466 | 0.81 | SMN1; SMN2 (0.47) | MAPTSMN1; SMN2POLBALDH1A1 | |
| SCHEMBL29033382 | 0.79 | ALDH1A1 (0.57) | NPC1RAB9AMAPTSMN1; SMN2KMT2A | |
| SCHEMBL14714515 | 0.79 | RAB9A (0.53) | NPC1RAB9ACTDSP1MAPTSMN1; SMN2 | |
| SCHEMBL13479797 | 0.78 | ALDH1A1 (0.57) | NPC1RAB9AMAPTSMN1; SMN2KMT2A | |
| SCHEMBL28816809 | 0.78 | SMN1; SMN2 (0.50) | NPC1RAB9ASMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL28816806 | 0.78 | KMT2A (0.44) | NPC1RAB9AMAPTSMN1; SMN2KMT2A | |
| SCHEMBL6851695 | 0.77 | RAB9A (0.54) | NPC1RAB9ACTDSP1MAPTSMN1; SMN2 | |
| SCHEMBL6847442 | 0.76 | NPC1 (0.54) | NPC1RAB9ASMN1; SMN2KMT2ANR1H4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1389211-A1 | 3,7-DIAZYBICYCLO 3.3.1] FORMULATIONS AS ANTIARRHYTMIC COMPOUNDS | AstraZeneca AB (SE) | 2004-02-18 | — | — | EP | disclosed |
| EP-1389213-A1 | 3,7-DIAZABICYCLO 3.3.1] FORMULATIONS AS ANTIARHYTHMIC COMPOUNDS | AstraZeneca AB (SE) | 2004-02-18 | — | — | EP | disclosed |
| WO-2002083687-A1 | 3,7-DIAZYBICYCLO [3.3.1] FORMULATIONS AS ANTIARRHYTMIC COMPOUNDS | ASTRAZENECA AB (SE) | 2002-10-24 | — | — | WO | disclosed |
| WO-2002083688-A1 | 3,7-DIAZABICYCLO [3.3.1] FORMULATIONS AS ANTIARHYTHMIC COMPOUNDS | ASTRAZENECA AB (SE) | 2002-10-24 | — | — | WO | disclosed |