Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | PTGES2 | Q9H7Z7 | 2/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.39 |
| ▸ | KMO | O15229 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6859176 | 0.90 | ATM (0.49) | ATMTDP1PTGES2MAPTALDH1A1 | |
| SCHEMBL3622509 | 0.81 | ATM (0.51) | ATMTDP1CYP3A4CYP2C9MAPT | |
| SCHEMBL3515437 | 0.77 | HCAR3 (0.52) | ATMTDP1MAPTALDH1A1MAPK1 | |
| SCHEMBL856209 | 0.76 | CYP3A4 (0.57) | CYP3A4CYP2C9CYP2C19HSD17B10LMNA | |
| SCHEMBL31481963 | 0.76 | MAPT (0.57) | ATMTDP1MAPTALDH1A1MAPK1 | |
| SCHEMBL3512219 | 0.76 | MAPT (0.57) | ATMTDP1MAPTALDH1A1MAPK1 | |
| SCHEMBL2060752 | 0.75 | ATM (0.53) | ATMTDP1MAPTALDH1A1LMNA | |
| SCHEMBL14964656 | 0.75 | ALDH1A1 (0.55) | CYP3A4CYP2C9CYP2C19BRD4MAPT | |
| SCHEMBL1283854 | 0.74 | MAPT (0.54) | ATMTDP1MAPTALDH1A1MAPK1 | |
| SCHEMBL29705127 | 0.74 | TDP1 (0.58) | ATMTDP1CYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1406884-A1 | ARYLSUSFONAMIDE COMPOUNDS FOR THE TREATMENT OF OBESITY, TYPE II DIABETES AND CNS-DISORDERS | BIOVITRUM AB (SE) | 2004-04-14 | — | — | EP | disclosed |
| WO-2002092585-A1 | NOVEL, ARYLSUSFONAMIDE COMPOUNDS FOR THE TREATMENT OF OBESITY, TYPE II DIABETES AND CNS-DISORDERS | BIOVITRUM AB (SE) | 2002-11-21 | — | — | WO | disclosed |