Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 11/20 | 0.45 |
| ▸ | CES1 | P23141 | 2/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.40 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9094687 | 0.83 | KCNJ1 (0.47) | KCNJ1KCNH2LTA4HCES1CHRNA7 | |
| SCHEMBL3373791 | 0.82 | LTA4H (0.50) | KCNJ1KCNH2LTA4HCES1CHRNA7 | |
| SCHEMBL28330442 | 0.82 | RAB9A (0.48) | KCNJ1KCNH2LTA4HCHRNA7CHRNA10 | |
| SCHEMBL27679590 | 0.79 | KCNJ1 (0.49) | KCNJ1KCNH2LTA4HCES1CHRNA7 | |
| SCHEMBL17254244 | 0.79 | KCNJ1 (0.49) | KCNJ1KCNH2LTA4HCES1CHRNA7 | |
| SCHEMBL6852157 | 0.79 | KCNJ1 (0.49) | KCNJ1KCNH2LTA4HCES1CHRNA7 | |
| SCHEMBL722557 | 0.78 | LTA4H (0.64) | KCNJ1KCNH2LTA4HEPHX2CHRNA7 | |
| SCHEMBL28225164 | 0.75 | KCNJ1 (0.49) | KCNJ1KCNH2LTA4HCES1CHRNA7 | |
| SCHEMBL28362996 | 0.75 | LTA4H (0.62) | KCNJ1KCNH2LTA4HCES1CHRNA7 | |
| SCHEMBL28257875 | 0.75 | LTA4H (0.62) | KCNJ1KCNH2LTA4HEPHX2CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1585775-A | 6-O-acyl ketolide derivatives of erythromycine useful as antibacterials | ORTHO MCNEIL PHARM INC (US) | 2005-02-23 | — | — | CN | disclosed |
| US-6825170-B2 | ERYTHROMYCIN TYPE MACROLIDE WITH A FUSED OXAZOLONE RING | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2004-11-30 | — | — | US | disclosed |
| EP-1453847-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003050132-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2003-06-19 | — | — | WO | disclosed |