Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 5/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.40 |
| ▸ | EYA3 | Q99504 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
| ▸ | TTR | P02766 | 2/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3380979 | 0.82 | ALDH1A1 (0.40) | CYP2C19PTPN1MAPTHSD17B10ALDH1A1 | |
| SCHEMBL2775764 | 0.80 | CYP2C19 (0.50) | CYP2C19PTPN1MAPTHSD17B10ALDH1A1 | |
| SCHEMBL12499206 | 0.77 | NPSR1 (0.40) | CYP2C19MAPTHSD17B10ALDH1A1CYP3A4 | |
| SCHEMBL2256874 | 0.76 | KDM4E (0.46) | CYP2C19PTPN1MAPTHSD17B10ALDH1A1 | |
| SCHEMBL4250447 | 0.76 | CA12 (0.39) | CYP2C19PTPN1MAPTHSD17B10ALDH1A1 | |
| SCHEMBL28018757 | 0.74 | PTPN1 (0.55) | PTPN1EYA3TTR | |
| SCHEMBL11901872 | 0.73 | MAPT (0.60) | PTPN1MAPTCYP3A4MEN1LMNA | |
| SCHEMBL13348986 | 0.73 | ABCB1 (0.46) | CYP2C19PTPN1MAPTHSD17B10ALDH1A1 | |
| SCHEMBL595885 | 0.72 | ALDH1A1 (0.41) | CYP2C19MAPTHSD17B10ALDH1A1CYP3A4 | |
| SCHEMBL2483045 | 0.72 | MAOA (0.53) | CYP2C19MAPTHSD17B10ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6780859-B2 | FOR THERAPY OF DIABETES, OBESITY, IMPAIRED GLUCOSE TOLERANCE, GASTROINTESTINAL DISORDERS, HYPERTRIGLYCERIDEMIA, HYPERCHOLESTEOLEMIA, ATHEROSCLEROTIC DISORDERS, OR CARDIOVASCULAR DISORDERS | BAYER PHARMACEUTICALS CORPORATION | 2004-08-24 | — | — | US | disclosed |