Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 9/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | SLC6A1 | P30531 | 2/20 | 0.41 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2897015 | 0.92 | KIF11 (0.61) | KIF11SLC6A1SLC6A11KCNH2 | |
| SCHEMBL1263156 | 0.92 | KIF11 (0.61) | KIF11SLC6A1SLC6A11KCNH2 | |
| SCHEMBL26068376 | 0.92 | KIF11 (0.61) | KIF11SLC6A1SLC6A11KCNH2 | |
| Succinic Acid SCHEMBL8741640 | 0.83 | LMNA (0.40) | KIF11HTTNPSR1 | |
| SCHEMBL3487683 | 0.79 | KIF11 (0.50) | KIF11SLC6A1SLC6A11KCNH2 | |
| SCHEMBL30861823 | 0.79 | SLC6A11 (0.53) | KIF11PDE4BSLC6A1SLC6A11NPC1 | |
| SCHEMBL13388489 | 0.79 | KIF11 (0.50) | KIF11SLC6A1SLC6A11KCNH2 | |
| SCHEMBL16214813 | 0.79 | KIF11 (0.50) | KIF11SLC6A1SLC6A11KCNH2 | |
| SCHEMBL3490250 | 0.78 | KIF11 (0.49) | KIF11SLC6A1SLC6A11KCNH2 | |
| SCHEMBL9508740 | 0.78 | KIF11 (0.49) | KIF11SLC6A1SLC6A11KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6828427-B1 | Oligomeric aminodiol-containing compounds, libraries thereof, and process of preparing the same | ISIS PHARMACEUTICALS, INC. | 2004-12-07 | — | — | US | disclosed |
| EP-0751948-B1 | NOVEL PHOSPHORAMIDATE AND PHOPHOROTHIOAMIDATE OLIGOMERIC COMPOUNDS | ISIS PHARMACEUTICALS INC (US) | 2002-09-25 | — | — | EP | disclosed |
| US-6184389-B1 | FEATURE A PLURALITY OF FUNCTIONAL GROUPS ATTACHED TO BACKBONE AND PHOSPHORAMIDATE SITES | ISIS PHARMACEUTICALS, INC. | 2001-02-06 | — | — | US | disclosed |
| US-5717083-A | COMPLEXING WITH PROTEINS, NUCLEIC ACIDS, LIPIDS | ISIS PHARMACEUTICALS, INC. (US) | 1998-02-10 | — | — | US | disclosed |
| EP-0751948-A4 | NOVEL PHOSPHORAMIDATE AND PHOPHOROTHIOAMIDATE OLIGOMERIC COMPOUNDS | ISIS PHARMACEUTICALS INC (US) | 1997-03-19 | — | — | EP | disclosed |
| EP-0751948-A1 | NOVEL PHOSPHORAMIDATE AND PHOPHOROTHIOAMIDATE OLIGOMERIC COMPOUNDS | ISIS PHARMACEUTICALS, INC. (US) | 1997-01-08 | — | — | EP | disclosed |
| WO-1995023160-A1 | NOVEL PHOSPHORAMIDATE AND PHOPHOROTHIOAMIDATE OLIGOMERIC COMPOUNDS | ISIS PHARMACEUTICALS, INC. (US) | 1995-08-31 | — | — | WO | disclosed |