Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAT2A | P31153 | 2/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | CHKA | P35790 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6855823 | 0.84 | PIM1 (0.35) | NPC1RAB9APIM1PIM2ALDH1A1 | |
| SCHEMBL6858242 | 0.82 | HPGD (0.41) | HPGDTSHRSMN1; SMN2GFERALDH1A1 | |
| SCHEMBL6858355 | 0.80 | ALDH1A1 (0.33) | HPGDTSHRRAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6855784 | 0.75 | MAPT (0.46) | MAT2AHRH4HTR3AHPGDTSHR | |
| SCHEMBL6850076 | 0.75 | MAPT (0.46) | MAT2AHRH4HTR3AHPGDTSHR | |
| SCHEMBL6854165 | 0.75 | MAPT (0.46) | MAT2AHRH4HTR3AHPGDTSHR | |
| SCHEMBL6855846 | 0.73 | MAPT (0.46) | HRH4HTR3AHPGDTSHRSMN1; SMN2 | |
| SCHEMBL6850089 | 0.72 | PLK1 (0.44) | HPGDTP53ALDH1A1HSD17B10LMNA | |
| SCHEMBL6858251 | 0.71 | ALDH1A1 (0.50) | MAT2AHPGDTSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL6853905 | 0.71 | L3MBTL1 (0.47) | TP53ALDH1A1LMNAPOLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6828315-B1 | Anti- inflammatories, anti-allergics, bronchodilatators, anti-asthmatics, or TNF alpha inhibitors | WARNER-LAMBERT LLC | 2004-12-07 | — | — | US | disclosed |
| EP-1177195-B1 | 1-AMINO TRIAZOLO 4,3-a! QUINAZOLINE-5-ONES AND OR -5-THIONES INHIBITING PHOSPHODIESTERASE IV | WARNER LAMBERT CO (US) | 2003-03-19 | — | — | EP | disclosed |