⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL442365 | 0.85 | — | — | |
| SCHEMBL22367664 | 0.74 | — | — | |
| SCHEMBL7906814 | 0.72 | — | — | |
| SCHEMBL28380914 | 0.70 | SMPD1 (0.30) | — | |
| SCHEMBL28630073 | 0.69 | — | — | |
| SCHEMBL7454401 | 0.65 | TSHR (0.35) | — | |
| SCHEMBL1550730 | 0.65 | — | — | |
| SCHEMBL3266280 | 0.63 | — | — | |
| SCHEMBL6854959 | 0.61 | — | — | |
| SCHEMBL2112764 | 0.61 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487855-A2 | METHOD OF USING MODIFIED OLIGONUCLEOTIDES FOR HEPATIC DELIVERY | ISIS Pharmaceuticals, Inc. (US) | 2004-12-22 | — | — | EP | disclosed |
| WO-2003072711-A2 | METHOD OF USING MODIFIED OLIGONUCLEOTIDES FOR HEPATIC DELIVERY | ISIS PHARMACEUTICALS, INC. (US) | 2003-09-04 | — | — | WO | disclosed |