Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6849824 | 0.90 | MAPT (0.39) | MAPTKDM4EPOLBL3MBTL1TDP1 | |
| SCHEMBL6855762 | 0.86 | MAPT (0.37) | MAPTKDM4EPOLBL3MBTL1TDP1 | |
| SCHEMBL6855298 | 0.84 | NPSR1 (0.39) | MAPTKDM4EPOLBL3MBTL1TDP1 | |
| SCHEMBL22040162 | 0.83 | ADORA1 (0.45) | MAPTKDM4EPOLBL3MBTL1TDP1 | |
| SCHEMBL7473914 | 0.80 | KMT2A (0.39) | MAPTKDM4EPOLBL3MBTL1TDP1 | |
| SCHEMBL6854520 | 0.80 | MAPT (0.38) | MAPTKDM4EPOLBL3MBTL1TDP1 | |
| SCHEMBL6854964 | 0.79 | NOTUM (0.40) | MAPTKDM4EPOLBL3MBTL1TDP1 | |
| SCHEMBL11851306 | 0.74 | LMNA (0.35) | SMN1; SMN2ADORA2AADORA1ADORA3CYP3A4 | |
| SCHEMBL6853833 | 0.74 | NOTUM (0.39) | MAPTKDM4ETDP1SMN1; SMN2ALDH1A1 | |
| SCHEMBL6855527 | 0.72 | GAA (0.38) | MAPTSMN1; SMN2NPC1ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6831177-B1 | Preparation of their intermediates, 2-acyl-5-benzylfuran derivatives and 1,2,4-triazole-3- carboxylic acid ester derivatives | SHIONOGI & CO., LTD. (JP) | 2004-12-14 | — | — | US | disclosed |
| EP-1186599-A1 | NOVEL PROCESSES FOR THE PREPARATION OF SUBSTITUTED PROPENONE DERIVATIVES | SHIONOGI & CO., LTD. (JP) | 2002-03-13 | — | — | EP | disclosed |