Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.49 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.45 |
| ▸ | NPY1R | P25929 | 3/20 | 0.45 |
| ▸ | NPY4R | P50391 | 3/20 | 0.45 |
| ▸ | MMP3 | P08254 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 3/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29577662 | 0.97 | SIRT5 (0.53) | SIRT5NPY1RNPY4RMMP3TDP1 | |
| SCHEMBL29417414 | 0.97 | SIRT5 (0.53) | SIRT5NPY1RNPY4RMMP3TDP1 | |
| SCHEMBL5523268 | 0.97 | SIRT5 (0.53) | SIRT5NPY1RNPY4RMMP3TDP1 | |
| Hydrochloric Acid SCHEMBL29692733 | 0.96 | SIRT5 (0.52) | SIRT5NPY1RNPY4RMMP3TDP1 | |
| SCHEMBL1300474 | 0.94 | SIRT5 (0.46) | SIRT5NPY5RNPY1RNPY4RTDP1 | |
| SCHEMBL31045936 | 0.94 | SIRT5 (0.52) | SIRT5NPY1RNPY4RMMP3TDP1 | |
| SCHEMBL13276502 | 0.93 | TDP1 (0.44) | SIRT5MMP3TDP1KDM4EALDH1A1 | |
| SCHEMBL29355408 | 0.93 | TDP1 (0.44) | SIRT5MMP3TDP1KDM4EALDH1A1 | |
| SCHEMBL4727432 | 0.93 | SIRT2 (0.49) | SIRT5TDP1RAB9ASIRT1SIRT2 | |
| SCHEMBL4076285 | 0.93 | SIRT2 (0.49) | SIRT5TDP1RAB9ASIRT1SIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6781000-B1 | FOR INHIBITING CELL PROLIFERATION DISORDERS, INFECTIOUS DISEASES, AND IMMUNOLOGICAL DISEASES IN MAMMALS, AND ESPECIALLY IN HUMANS | CV THEURAPEUTICS, INC. | 2004-08-24 | — | — | US | disclosed |
| EP-1058689-A1 | ALPHA-KETOAMIDE INHIBITORS OF 20S PROTEASOME | CV THERAPEUTICS, INC. (US) | 2000-12-13 | — | — | EP | disclosed |
| US-6075150-A | A CELL ANTIPROLIFERATIVE AGENT | CV THERAPEUTICS, INC. (US) | 2000-06-13 | — | — | US | disclosed |
| WO-1999037666-A1 | α-KETOAMIDE INHIBITORS OF 20S PROTEASOME | CV THERAPEUTICS, INC. (US) | 1999-07-29 | — | — | WO | disclosed |