Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.56 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.56 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.56 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.56 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.56 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.56 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.56 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.56 |
| ▸ | THRA | P10827 | 1/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.50 |
| ▸ | BAD | Q92934 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8996663 | 0.96 | SIGMAR1 (0.56) | ALDH1A1MEN1KMT2ALMNASIGMAR1 | |
| SCHEMBL6719089 | 0.86 | MEN1 (0.49) | ALDH1A1MEN1KMT2ALMNASIGMAR1 | |
| SCHEMBL6719061 | 0.86 | ALDH1A1 (0.48) | ALDH1A1MEN1KMT2ALMNASIGMAR1 | |
| SCHEMBL17894510 | 0.86 | SIGMAR1 (0.61) | ALDH1A1MEN1KMT2ALMNASIGMAR1 | |
| SCHEMBL18917078 | 0.84 | SIGMAR1 (0.60) | ALDH1A1MEN1KMT2ALMNASIGMAR1 | |
| SCHEMBL6720727 | 0.82 | LMNA (0.54) | ALDH1A1MEN1KMT2ALMNASIGMAR1 | |
| SCHEMBL6716539 | 0.82 | ALDH1A1 (0.46) | ALDH1A1MEN1KMT2ALMNASIGMAR1 | |
| SCHEMBL4512661 | 0.82 | ALDH1A1 (0.55) | ALDH1A1MEN1KMT2ALMNASIGMAR1 | |
| SCHEMBL9293166 | 0.82 | SIGMAR1 (0.61) | ALDH1A1MEN1KMT2ALMNASIGMAR1 | |
| SCHEMBL6717182 | 0.81 | NPC1 (0.50) | ALDH1A1MEN1KMT2ALMNASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6787569-B1 | INHIBITORS OF NEUROTRANSMITTER (E.G., GLUTAMATE) RELEASE FROM ISCHEMIC NEURONAL CELLS; N,N-DISUBSTITUTED GUANIDINES; NEUROLOGICAL CONDITIONS SUCH AS EPILEPSY, NEURODEGENERATIVE CONDITIONS AND/OR NERVE CELL DEATH FROM STROKE OR HEART ATTACK | CAMBRIDGE NEUROSCIENCE, INC. | 2004-09-07 | — | — | US | disclosed |