Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR2 | P50052 | 12/20 | 0.71 |
| ▸ | AGTR1 | P30556 | 11/20 | 0.71 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.71 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.71 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.71 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.71 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.71 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.71 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.71 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Olmesartan Medoxomil SCHEMBL96150 | 0.95 | AGTR2 (0.79) | AGTR2AGTR1ABCC3ABCC4ABCB11 | |
| SCHEMBL15132375 | 0.94 | AGTR2 (0.72) | AGTR2AGTR1ABCC3ABCC4ABCB11 | |
| SCHEMBL8534578 | 0.93 | AGTR2 (0.63) | AGTR2AGTR1ABCC3ABCC4ABCB11 | |
| SCHEMBL2626709 | 0.92 | AGTR2 (0.69) | AGTR2AGTR1ABCC3ABCC4ABCB11 | |
| SCHEMBL2844872 | 0.91 | AGTR2 (0.73) | AGTR2AGTR1ABCC3ABCC4ABCB11 | |
| SCHEMBL7302860 | 0.89 | AGTR2 (0.71) | AGTR2AGTR1ABCC3ABCC4ABCB11 | |
| SCHEMBL669266 | 0.89 | AGTR2 (0.66) | AGTR2AGTR1ABCC3ABCC4ABCB11 | |
| SCHEMBL4019176 | 0.89 | AGTR1 (0.70) | AGTR2AGTR1ABCC3ABCC4ABCB11 | |
| SCHEMBL6434240 | 0.88 | AGTR2 (0.70) | AGTR2AGTR1ABCC3ABCC4ABCB11 | |
| SCHEMBL7886557 | 0.87 | AGTR2 (0.68) | AGTR2AGTR1ABCC3ABCC4ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012069025-A1 | (5-METHYL-2-OXO-1,3-DIOXOL-4-YLMETHYL)-4-(1-HYDROXY-1-METHYL-PROPYL)-2-PROPYL-1-[2'- (1H-TETRAZOL-5-YL)BIPHENYL-4-YL-METHYL]IMIDAZOLE-5-CARBOXYLATE AS AN IMPURITY OF OLMESARTAN MEDOXOMIL AND A METHOD OF ITS PREPARATION | ZENTIVA, K.S. (CZ) | 2012-05-31 | — | — | WO | disclosed |
| WO-2012069025-A1 | (5-METHYL-2-OXO-1,3-DIOXOL-4-YLMETHYL)-4-(1-HYDROXY-1-METHYL-PROPYL)-2-PROPYL-1-[2'- (1H-TETRAZOL-5-YL)BIPHENYL-4-YL-METHYL]IMIDAZOLE-5-CARBOXYLATE AS AN IMPURITY OF OLMESARTAN MEDOXOMIL AND A METHOD OF ITS PREPARATION | ZENTIVA, K.S. (CZ) | 2012-05-31 | — | — | WO | disclosed |
| WO-2012069025-A1 | (5-METHYL-2-OXO-1,3-DIOXOL-4-YLMETHYL)-4-(1-HYDROXY-1-METHYL-PROPYL)-2-PROPYL-1-[2'- (1H-TETRAZOL-5-YL)BIPHENYL-4-YL-METHYL]IMIDAZOLE-5-CARBOXYLATE AS AN IMPURITY OF OLMESARTAN MEDOXOMIL AND A METHOD OF ITS PREPARATION | ZENTIVA, K.S. (CZ) | 2012-05-31 | — | — | WO | disclosed |
| WO-2011007368-A2 | AN IMPROVED PROCESS FOR PREPARATION OF OLMESARTAN | CADILA HEALTHCARE LIMITED (IN) | 2011-01-20 | — | — | WO | disclosed |