Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 15/20 | 0.68 |
| ▸ | ACE2 | Q9BYF1 | 13/20 | 0.68 |
| ▸ | ACE | P12821 | 13/20 | 0.68 |
| ▸ | CPA1 | P15085 | 11/20 | 0.68 |
| ▸ | ACACB | O00763 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | CTSS | P25774 | 1/20 | 0.56 |
| ▸ | CTSK | P43235 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6436289 | 1.00 | MME (0.68) | MMEACE2ACECPA1ACACB | |
| SCHEMBL6436295 | 1.00 | MME (0.68) | MMEACE2ACECPA1ACACB | |
| Afalanine SCHEMBL331330 | 0.91 | CTSS (0.65) | MMEACE2ACECPA1LMNA | |
| Afalanine SCHEMBL158612 | 0.91 | CTSS (0.65) | MMEACE2ACECPA1LMNA | |
| Afalanine SCHEMBL8587729 | 0.91 | CTSS (0.65) | MMEACE2ACECPA1LMNA | |
| Afalanine SCHEMBL158613 | 0.91 | CTSS (0.65) | MMEACE2ACECPA1LMNA | |
| SCHEMBL23512376 | 0.90 | MME (0.61) | MMEACE2ACECPA1ACACB | |
| Afalanine SCHEMBL8054567 | 0.90 | CTSS (0.63) | MMEACE2ACECPA1LMNA | |
| Afalanine SCHEMBL5493802 | 0.90 | CTSS (0.68) | MMEACE2ACECPA1LMNA | |
| Afalanine SCHEMBL8054139 | 0.90 | CTSS (0.63) | MMEACE2ACECPA1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115304597-A | Beta-carboline compounds and application thereof in preparing medicines for treating or preventing tumor diseases | 中国科学院深圳先进技术研究院 | 2022-11-08 | — | — | CN | disclosed |
| US-9624163-B2 | Process for preparing intermediates useful in the manufacture of NEP inhibitors | NOVARTIS AG (CH) | 2017-04-18 | — | — | US | disclosed |
| EP-2480523-B1 | PROCESS FOR MANUFACTURE OF N-ACYLBPHENYL ALANINE | ZHEJIANG JIUZHOU PHARM CO LTD (CN) | 2017-03-01 | — | — | EP | disclosed |
| US-20160115118-A1 | PROCESS FOR THE MANUFACTURE OF N-ACYLBIPHENYL ALANINE | ZHEJIANG JIUZHOU PHARMACEUTICAL CO., LTD. (CN) | 2016-04-28 | — | — | US | disclosed |
| US-20160115118-A1 | PROCESS FOR THE MANUFACTURE OF N-ACYLBIPHENYL ALANINE | ZHEJIANG JIUZHOU PHARMACEUTICAL CO., LTD. (CN) | 2016-04-28 | — | — | US | disclosed |
| US-9242927-B2 | Process for the manufacture of N-acylbiphenyl alanine | ZHEJIANG JIUZHOU PHARMACEUTICAL CO., LTD (CN) | 2016-01-26 | — | — | US | disclosed |
| US-9242927-B2 | Process for the manufacture of N-acylbiphenyl alanine | ZHEJIANG JIUZHOU PHARMACEUTICAL CO., LTD (CN) | 2016-01-26 | — | — | US | disclosed |
| US-9181175-B2 | Process for manufacture and resolution of 2-acylamino-3-diphenylpropanoic acid | Zhejiang Jiuzhous Pharmaceutical Co., Ltd. (CN) | 2015-11-10 | — | — | US | disclosed |
| US-9181175-B2 | Process for manufacture and resolution of 2-acylamino-3-diphenylpropanoic acid | Zhejiang Jiuzhous Pharmaceutical Co., Ltd. (CN) | 2015-11-10 | — | — | US | disclosed |
| US-20150210632-A1 | NEW PROCESS | NOVARTIS AG (CH) | 2015-07-30 | — | — | US | disclosed |
| US-20140179947-A1 | PROCESS FOR MANUFACTURE AND RESOLUTION OF 2-ACYLAMINO-3-DIPHENYLPROPANOIC ACID | ZHEJIANG JIUZHOU PHARMACEUTICAL CO., LTD. (CN) | 2014-06-26 | — | — | US | disclosed |
| US-20140179947-A1 | PROCESS FOR MANUFACTURE AND RESOLUTION OF 2-ACYLAMINO-3-DIPHENYLPROPANOIC ACID | ZHEJIANG JIUZHOU PHARMACEUTICAL CO., LTD. (CN) | 2014-06-26 | — | — | US | disclosed |
| US-20140142320-A1 | Process for the Manufacture of N-acylbiphenyl alanine | ZHEJIANG JIUZHOU PHARMACEUTICAL CO., LTD. (CN) | 2014-05-22 | — | — | US | disclosed |
| US-20140142320-A1 | Process for the Manufacture of N-acylbiphenyl alanine | ZHEJIANG JIUZHOU PHARMACEUTICAL CO., LTD. (CN) | 2014-05-22 | — | — | US | disclosed |
| US-20130172572-A1 | Process for Manufacture of N-acylbiphenyl alanine | ZHEJIANG JIUZHOU PHARMACEUTICAL CO., LTD. (CN) | 2013-07-04 | — | — | US | disclosed |
| US-20130172572-A1 | Process for Manufacture of N-acylbiphenyl alanine | ZHEJIANG JIUZHOU PHARMACEUTICAL CO., LTD. (CN) | 2013-07-04 | — | — | US | disclosed |
| US-20120016151-A1 | PROCESS FOR MANUFACTURE AND RESOLUTION OF 2-ACYLAMINO-3-DIPHENYLPROPANOIC ACID | NOVARTIS AG (CH) | 2012-01-19 | — | — | US | disclosed |
| US-20120016151-A1 | PROCESS FOR MANUFACTURE AND RESOLUTION OF 2-ACYLAMINO-3-DIPHENYLPROPANOIC ACID | NOVARTIS AG (CH) | 2012-01-19 | — | — | US | disclosed |
| WO-2011035569-A1 | PROCESS FOR MANUFACTURE OF N-ACYLBPHENYL ALANINE | ZHEJIANG JIUZHOU PHARMACEUTICAL CO., LTD. (CN) | 2011-03-31 | — | — | WO | disclosed |
| WO-2010081410-A1 | PROCESS FOR MANUFACTURE AND RESOLUTION OF 2-ACYLAMINO-3-DIPHENYLPROPANOIC ACID | ZHEJIANG JIUZHOU PHARMACEUTICAL CO., LTD. (CN) | 2010-07-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160115118-A1 | PROCESS FOR THE MANUFACTURE OF N-ACYLBIPHENYL ALANINE | ANPEP, DNPEP, ENPEP | MME 7/4885ACE2 86/4885ACE 31/4885 |
| US-20150210632-A1 | NEW PROCESS | MME, DNPEP, ACE | MME 1/4885ACE2 13/4885ACE 3/4885 |
| US-20140179947-A1 | PROCESS FOR MANUFACTURE AND RESOLUTION OF 2-ACYLAMINO-3-DIPHENYLPROPANOIC ACID | DNPEP, MME, DPP7 | MME 2/4885ACE2 79/4885ACE 29/4885 |
| US-20120016151-A1 | PROCESS FOR MANUFACTURE AND RESOLUTION OF 2-ACYLAMINO-3-DIPHENYLPROPANOIC ACID | DNPEP, MME, DPP7 | MME 2/4885ACE2 79/4885ACE 29/4885 |
| US-20140142320-A1 | Process for the Manufacture of N-acylbiphenyl alanine | ANPEP, DNPEP, ENPEP | MME 7/4885ACE2 86/4885ACE 31/4885 |
| US-20130172572-A1 | Process for Manufacture of N-acylbiphenyl alanine | ANPEP, DNPEP, RNPEP | MME 6/4885ACE2 107/4885ACE 35/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.