SCHEMBL6857979

SCHEMBL6857979

Cc1cccc([SiH2]N)c1C

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 2/20 0.42
ATM Q13315 1/20 0.42
CYP1A2 P05177 1/20 0.38
CYP2A6 P11509 1/20 0.38
CD44 P16070 1/20 0.37
TSHR P16473 3/20 0.36
MAPT P10636 2/20 0.36
ACHE P22303 1/20 0.36
ALDH1A1 P00352 3/20 0.36
CYP3A4 P08684 2/20 0.36
CA1 P00915 1/20 0.36
CA2 P00918 1/20 0.36
CA7 P43166 1/20 0.36
CA9 Q16790 1/20 0.36
PIK3CA P42336 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.35
TDP1 Q9NUW8 2/20 0.34
KEAP1 Q14145 1/20 0.33
NFE2L2 Q16236 1/20 0.33
MAOA P21397 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18860810 0.79
SCHEMBL29776862 0.77 TRPA1 (0.44) TRPA1ATMCYP1A2CYP2A6CD44
SCHEMBL10696455 0.77 TRPA1 (0.44) TRPA1ATMCYP1A2CYP2A6CD44
SCHEMBL3200651 0.75 TRPA1 (0.42) TRPA1ATMCYP1A2CYP2A6CD44
SCHEMBL8967412 0.75 TRPA1 (0.42) TRPA1ATMCYP1A2CYP2A6CD44
SCHEMBL2175294 0.75 TRPA1 (0.48) TRPA1ATMCYP1A2CYP2A6CD44
SCHEMBL7768863 0.75 TRPA1 (0.42) TRPA1ATMCYP1A2CYP2A6CD44
SCHEMBL7179945 0.75 TRPA1 (0.42) TRPA1ATMCYP1A2CYP2A6CD44
SCHEMBL113990 0.75 TRPA1 (0.42) TRPA1ATMCYP1A2CYP2A6CD44
SCHEMBL7184237 0.75 TRPA1 (0.42) TRPA1ATMCYP1A2CYP2A6CD44

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117106483-A Residual oil hydrogenation anti-coking scale inhibitor and preparation method thereof 江苏创新石化有限公司 2023-11-24 CN claimed
CN-117106483-A Residual oil hydrogenation anti-coking scale inhibitor and preparation method thereof 江苏创新石化有限公司 2023-11-24 CN disclosed
US-6737193-B2 ACTIVE MATERIALS IN THE POSITIVE ELECTRODES OF BATTERIES. NOVEL METHODS FOR PREPARING THE TETRAKETOPIPERAZINE UNIT-CONTAINING COMPOUNDS INCLUDE: (I) REACTING AN OXALYL HALIDE AND AN OXAMIDE, AND ADDING WATER OR AN AQUEOUS ALKALI IM&T RESEARCH, INC. 2004-05-18 US disclosed
US-20030148188-A1 Active materials in the positive electrodes of batteries. Novel methods for preparing the tetraketopiperazine unit-containing compounds include: (i) reacting an oxalyl halide and an oxamide, and adding water or an aqueous alkali IM&T RESEARCH, INC. 2003-08-07 US disclosed
US-6130272-A FLUIDIZING REINFORCING SILICA FILLER IN HIGH-SHEAR MIXER; ADDING SILYLATING AGENT, NITROGEN COMPOUND SELECTED FROM AMMONIA, AMMONIA SALTS, NON-SILYLATED PRIMARY AMINES, AND AMINOXY COMPOUNDS, WATER; ADDING POLYDIORGANOSILOXAN; HEATING DOW CORNING CORPORATION (US) 2000-10-10 US disclosed
EP-0783021-A2 Process for making powdered base for formulating curable liquid silicone rubber composition DOW CORNING CORPORATION (US) 1997-07-09 EP disclosed