Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | POLQ | O75417 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | GCGR | P47871 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6862396 | 0.87 | POLB (0.45) | LMNATSHRNPSR1MAPTPOLB | |
| SCHEMBL6860631 | 0.86 | OPRD1 (0.43) | MAPTPOLBPOLQCYP1A2CYP2C9 | |
| SCHEMBL13521117 | 0.82 | LMNA (0.62) | LMNATSHRNPSR1MAPTPOLB | |
| SCHEMBL6860642 | 0.81 | SMN1; SMN2 (0.49) | LMNATSHRMAPTPOLBTP53 | |
| SCHEMBL12997897 | 0.81 | GRIA2 (0.53) | TSHRMAPTGAAKDM4ECYP1A2 | |
| SCHEMBL6860475 | 0.78 | LMNA (0.44) | LMNATSHRNPSR1MAPTPOLB | |
| SCHEMBL13521113 | 0.72 | LMNA (0.63) | LMNATSHRNPSR1MAPTTP53 | |
| SCHEMBL13773366 | 0.72 | MAPT (0.69) | LMNATSHRNPSR1MAPTPOLB | |
| SCHEMBL1007029 | 0.71 | LMNA (0.56) | LMNATSHRNPSR1MAPTPOLB | |
| SCHEMBL13521108 | 0.71 | LMNA (0.66) | LMNATSHRNPSR1MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011036889-A1 | HETEROCYCLIC COMPOUND | 武田薬品工業株式会社 (JP) | 2011-03-31 | — | — | WO | disclosed |