Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | PREP | P48147 | 1/20 | 0.53 |
| ▸ | FAP | Q12884 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.52 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.52 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.52 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.52 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.52 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.52 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL513251 | 0.87 | LMNA (0.60) | HDAC1HDAC6LMNANPC1RAB9A | |
| SCHEMBL2794824 | 0.87 | LMNA (0.60) | HDAC1HDAC6LMNANPC1RAB9A | |
| SCHEMBL2797592 | 0.87 | LMNA (0.60) | HDAC1HDAC6LMNANPC1RAB9A | |
| SCHEMBL29748479 | 0.87 | LMNA (0.60) | HDAC1HDAC6LMNANPC1RAB9A | |
| SCHEMBL30151637 | 0.87 | LMNA (0.60) | HDAC1HDAC6LMNANPC1RAB9A | |
| Hydrochloric Acid SCHEMBL8439654 | 0.86 | GPR132 (0.59) | HDAC1HDAC6LMNANPC1RAB9A | |
| SCHEMBL8804879 | 0.86 | LMNA (0.56) | HDAC1HDAC6LMNANPC1RAB9A | |
| SCHEMBL6574004 | 0.86 | LMNA (0.56) | HDAC1HDAC6LMNANPC1RAB9A | |
| SCHEMBL1106964 | 0.85 | HDAC1 (0.62) | HDAC1HDAC6LMNANPC1RAB9A | |
| SCHEMBL29589266 | 0.84 | ALDH1A1 (0.57) | HDAC1HDAC6LMNANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011089576-A2 | NOVEL COMPOSITIONS FOR REDUCING Aß 42 PRODUCTION AND THEIR USE IN TREATING ALZHEIMER'S DISEASE (AD) | KAREUS THERAPEUTTICS SA (CH) | 2011-07-28 | — | — | WO | disclosed |