Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YAP1 | P46937 | 3/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 6/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | KLK7 | P49862 | 2/20 | 0.37 |
| ▸ | GHSR | Q92847 | 3/20 | 0.37 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.37 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.37 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.37 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.37 |
| ▸ | BCL2 | P10415 | 1/20 | 0.36 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6868576 | 0.85 | GPR119 (0.37) | MMP13 | |
| SCHEMBL6861568 | 0.78 | YAP1 (0.41) | YAP1PRMT5MCL1LTA4HGHSR | |
| SCHEMBL6861095 | 0.77 | KLK7 (0.33) | KLK7KLK5 | |
| SCHEMBL6861270 | 0.75 | PRMT5 (0.43) | YAP1PRMT5MCL1LTA4HKLK7 | |
| SCHEMBL8222384 | 0.75 | PRMT5 (0.43) | YAP1PRMT5MCL1LTA4HKLK7 | |
| SCHEMBL353103 | 0.69 | KLK7 (0.43) | KLK7KLK5 | |
| SCHEMBL13701098 | 0.68 | YAP1 (0.44) | YAP1PRMT5KLK7GHSRMMP13 | |
| SCHEMBL190827 | 0.66 | NFKB1 (0.30) | — | |
| SCHEMBL13701096 | 0.66 | YAP1 (0.47) | YAP1PRMT5GHSR | |
| SCHEMBL21265993 | 0.66 | USP30 (0.53) | YAP1PRMT5MCL1LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1004578-B1 | 5-oxo-pyrrolidine-2-carboxylic acid hydroxamide derivatives | PFIZER PROD INC (US) | 2004-02-25 | — | — | EP | disclosed |
| US-6114361-A | INHIBITORS OF MATRIX METALLOPROTEINASES AND REPROLYSIN; ADMINISTERING TO TREAT CONDITIONS WHICH CAN BE TREATED BY THE INHIBITION OF THESE ENZYMES | PFIZER INC. (US) | 2000-09-05 | — | — | US | disclosed |
| EP-1004578-A2 | 5-oxo-pyrrolidine-2-carboxylic acid hydroxamide derivatives | Pfizer Products Inc. (US) | 2000-05-31 | — | — | EP | disclosed |