Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | YAP1 | P46937 | 3/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | GHSR | Q92847 | 3/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8229952 | 1.00 | YAP1 (0.40) | YAP1MMP13PRMT5TP53LTA4H | |
| SCHEMBL6866096 | 0.86 | MMP13 (0.44) | YAP1MMP13PRMT5TP53GHSR | |
| SCHEMBL6418068 | 0.80 | KLK7 (0.43) | — | |
| SCHEMBL6418070 | 0.80 | KLK7 (0.43) | — | |
| SCHEMBL8222384 | 0.79 | PRMT5 (0.43) | YAP1PRMT5LTA4HGHSRMCL1 | |
| SCHEMBL6861270 | 0.79 | PRMT5 (0.43) | YAP1PRMT5LTA4HGHSRMCL1 | |
| SCHEMBL29679804 | 0.76 | TOP2A (0.37) | — | |
| SCHEMBL24537587 | 0.76 | TOP2A (0.37) | — | |
| SCHEMBL6861568 | 0.74 | YAP1 (0.41) | YAP1MMP13PRMT5TP53LTA4H | |
| SCHEMBL13613732 | 0.74 | TOP2A (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1004578-B1 | 5-oxo-pyrrolidine-2-carboxylic acid hydroxamide derivatives | PFIZER PROD INC (US) | 2004-02-25 | — | — | EP | disclosed |
| US-6114361-A | INHIBITORS OF MATRIX METALLOPROTEINASES AND REPROLYSIN; ADMINISTERING TO TREAT CONDITIONS WHICH CAN BE TREATED BY THE INHIBITION OF THESE ENZYMES | PFIZER INC. (US) | 2000-09-05 | — | — | US | disclosed |
| EP-1004578-A2 | 5-oxo-pyrrolidine-2-carboxylic acid hydroxamide derivatives | Pfizer Products Inc. (US) | 2000-05-31 | — | — | EP | disclosed |