Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.52 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.52 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.48 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6866556 | 1.00 | LMNA (0.61) | LMNAHTTTRPV1HCRTR1HCRTR2 | |
| SCHEMBL6861666 | 1.00 | LMNA (0.61) | LMNAHTTTRPV1HCRTR1HCRTR2 | |
| SCHEMBL5962884 | 0.88 | LMNA (0.52) | LMNATRPV1HCRTR1HCRTR2ROCK2 | |
| SCHEMBL8632697 | 0.86 | LMNA (0.57) | LMNATRPV1HCRTR1HCRTR2MEN1 | |
| SCHEMBL18306276 | 0.86 | KMT2A (0.59) | LMNAHTTHCRTR1HCRTR2MEN1 | |
| SCHEMBL8632693 | 0.86 | LMNA (0.57) | LMNATRPV1HCRTR1HCRTR2MEN1 | |
| SCHEMBL5962928 | 0.85 | LMNA (0.49) | LMNATRPV1HCRTR1HCRTR2ROCK2 | |
| SCHEMBL30514851 | 0.83 | DRD2 (0.57) | LMNATRPV1HCRTR1HCRTR2ROCK2 | |
| SCHEMBL21177378 | 0.83 | DRD2 (0.57) | LMNATRPV1HCRTR1HCRTR2ROCK2 | |
| SCHEMBL21177380 | 0.83 | DRD2 (0.57) | LMNATRPV1HCRTR1HCRTR2ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6818772-B2 | DIETETICS, SLEEP DISORDERS, EATING DISORDERS, SEXUAL DISORDERS, CENTRAL NERVOUS SYSTEM DISORDERS, PSYCHOLOGICAL DISORDERS | ABBOTT LABORATORIES | 2004-11-16 | — | — | US | disclosed |
| US-20030229119-A1 | Antagonists of melanin concentrating hormone effects on the melanin concetrating hormone receptor | ABBVIE INC. | 2003-12-11 | — | — | US | disclosed |
| US-6147159-A | SUPPORT FOR USE IN SOLID PHASE SYNTHESIS COMPRISING A LINKER GROUP MADE BY HYDROSILATION OF A SOLID SUPPORT HAVING AN ALKENE EXTENDING THEREFROM WITH A DIHYDROGEN SILANE COMPOUND SUCH AS DIHALOSILANE, DIALKOXYSILANE, OR DIALKYLSILANE | ARGONAUT TECHNOLOGIES (US) | 2000-11-14 | — | — | US | disclosed |
| WO-1999017869-A2 | COMPOSITIONS FOR ORGANIC SYNTHESIS ON SOLID PHASE AND METHODS OF USING THE SAME | ARGONAUT TECHNOLOGIES (US) | 1999-04-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030229119-A1 | Antagonists of melanin concentrating hormone effects on the melanin concetrating hormone receptor | MCHR1, MCHR2, MC1R | LMNA 3981/4885HTT 76/4885TRPV1 369/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.