Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 7/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.51 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.51 |
| ▸ | SCN1A | P35498 | 1/20 | 0.49 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.49 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8632693 | 1.00 | LMNA (0.57) | LMNASPHK2TSHRALDH1A1GAA | |
| SCHEMBL6866556 | 0.86 | LMNA (0.61) | LMNATSHRTP53MEN1KMT2A | |
| SCHEMBL6861666 | 0.86 | LMNA (0.61) | LMNATSHRTP53MEN1KMT2A | |
| SCHEMBL6861673 | 0.86 | LMNA (0.61) | LMNATSHRTP53MEN1KMT2A | |
| SCHEMBL8636082 | 0.82 | TSHR (0.54) | LMNATSHRALDH1A1GAATP53 | |
| SCHEMBL8632678 | 0.82 | TSHR (0.54) | LMNATSHRALDH1A1GAATP53 | |
| SCHEMBL7393837 | 0.82 | ALDH1A1 (0.60) | LMNATSHRALDH1A1GAATP53 | |
| SCHEMBL20040339 | 0.80 | HCRTR1 (0.67) | LMNASPHK2TSHRMEN1KMT2A | |
| SCHEMBL8633642 | 0.79 | HCRTR1 (0.53) | LMNASPHK2GAATP53MEN1 | |
| SCHEMBL8633638 | 0.79 | HCRTR1 (0.53) | LMNASPHK2GAATP53MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5847155-A | Aromatic pyrrolidine amide prolyl endopeptidase inhibitors | PFIZER INC (US) | 1998-12-08 | — | — | US | disclosed |
| EP-0536163-A1 | AROMATIC PYRROLIDINE AND THIAZOLIDINE AMIDES | PFIZER INC. (US) | 1993-04-14 | — | — | EP | disclosed |
| WO-1991018891-A1 | AROMATIC PYRROLIDINE AND THIAZOLIDINE AMIDES | PFIZER INC. (US) | 1991-12-12 | — | — | WO | disclosed |