Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 3/20 | 0.51 |
| ▸ | CNR1 | P21554 | 6/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.42 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | CAMKK1 | Q8N5S9 | 1/20 | 0.38 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6870813 | 0.85 | PIK3CA (0.50) | PIK3CACNR1MAPK1MAPKAPK2GRM4 | |
| SCHEMBL8956040 | 0.82 | PIK3CA (0.62) | PIK3CAMAPK1HPGDMAPKAPK2GRM4 | |
| Acetic Acid SCHEMBL27408297 | 0.79 | PIK3CA (0.55) | PIK3CAMAPK1MAPKAPK2GRM4CAMKK1 | |
| SCHEMBL6862365 | 0.78 | PIK3CA (0.51) | PIK3CACNR1MAPK1HPGDMAPKAPK2 | |
| SCHEMBL16633077 | 0.75 | RORC (0.49) | HPGD | |
| SCHEMBL5653842 | 0.73 | PIK3CA (0.62) | PIK3CAHPGDCYP19A1CAMKK1CAMKK2 | |
| SCHEMBL756718 | 0.73 | GRM4 (0.64) | PIK3CAMAPK1GRM4 | |
| Nitric Acid SCHEMBL6873528 | 0.73 | FNTA (0.58) | CNR1MAPK1HPGDCYP19A1 | |
| SCHEMBL9709110 | 0.73 | PIK3CA (0.87) | PIK3CAMAPKAPK2CAMKK1CAMKK2 | |
| SCHEMBL28104399 | 0.73 | ACVR1 (0.50) | PIK3CAMAPK1HPGDGRM4NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1106610-B1 | Farnesyl transferase inhibiting 2-quinolone derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2004-06-16 | — | — | EP | disclosed |
| CN-1101391-C | Farnesyl transferase inhibiting 2-quinolone derivatives | JANSSEN PHARMACEUTICA NV (BE) | 2003-02-12 | — | — | CN | disclosed |
| EP-1019395-B1 | FARNESYL TRANSFERASE INHIBITING 2-QUINOLONE DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2002-01-30 | — | — | EP | disclosed |
| EP-1106610-A1 | Farnesyl transferase inhibiting 2-quinolone derivatives | Janssen Pharmaceutica N.V. (BE) | 2001-06-13 | — | — | EP | disclosed |
| EP-1019395-A1 | FARNESYL TRANSFERASE INHIBITING 2-QUINOLONE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2000-07-19 | — | — | EP | disclosed |
| US-5968952-A | ANTITUMOR AGENTS | JANSSEN PHARMACEUTICA, N.V. (BE) | 1999-10-19 | — | — | US | disclosed |
| CN-1200732-A | Farnesyl transferase inhibiting 2-quinolone derivatives | JANSSEN PHARMACEUTICA NV (BE) | 1998-12-02 | — | — | CN | disclosed |
| WO-1997016443-A1 | FARNESYL TRANSFERASE INHIBITING 2-QUINOLONE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-05-09 | — | — | WO | disclosed |