Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 4/20 | 0.36 |
| ▸ | CA2 | P00918 | 4/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | MAT2A | P31153 | 4/20 | 0.34 |
| ▸ | IDO1 | P14902 | 4/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NOS3 | P29474 | 2/20 | 0.32 |
| ▸ | NOS1 | P29475 | 2/20 | 0.32 |
| ▸ | NOS2 | P35228 | 2/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA3 | P07451 | 1/20 | 0.32 |
| ▸ | CA4 | P22748 | 1/20 | 0.32 |
| ▸ | CA6 | P23280 | 1/20 | 0.32 |
| ▸ | CA5A | P35218 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.32 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.32 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31223911 | 0.62 | MAT2A (0.46) | NTRK1MAT2A | |
| SCHEMBL903681 | 0.57 | PIK3CA (0.34) | KMT2A | |
| SCHEMBL28277831 | 0.57 | OPRK1 (0.42) | MAT2AKMT2A | |
| SCHEMBL25412172 | 0.57 | MAT2A (0.41) | MAT2AKMT2ANOS3NOS1NOS2 | |
| SCHEMBL25411473 | 0.57 | MAT2A (0.41) | MAT2ANOS3NOS1NOS2MAPK8 | |
| SCHEMBL30727441 | 0.56 | MAT2A (0.50) | NTRK1MAT2A | |
| SCHEMBL22093343 | 0.56 | MAT2A (0.72) | MAT2A | |
| SCHEMBL25410818 | 0.55 | MAPK8 (0.38) | NTRK1MAT2AKMT2ACA12CA9 | |
| SCHEMBL21979009 | 0.55 | NQO2 (0.61) | NTRK1MAT2A | |
| SCHEMBL30901294 | 0.55 | NQO2 (0.61) | NTRK1MAT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011106650-A2 | NOVEL P53-MDM2/P53-MDM4 ANTAGONISTS TO TREAT PROLIFERATIVE DISEASE | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2011-09-01 | — | — | WO | disclosed |